Phenylephrine
- Generic Name
- Phenylephrine
- Brand Names
- 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13NO2
- CAS Number
- 59-42-7
- Unique Ingredient Identifier
- 1WS297W6MV
- Background
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Phenylephrine was granted FDA approval in 1939.
- Indication
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Effects of Phenylephrine Extended-Release Tablets on Allergy-Related Nasal Congestion (P08498 AM1)
- Conditions
- Interventions
- First Posted Date
- 2011-08-10
- Last Posted Date
- 2015-03-11
- Lead Sponsor
- Bayer
- Target Recruit Count
- 575
- Registration Number
- NCT01413958
Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2011-06-22
- Last Posted Date
- 2014-08-26
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 80
- Registration Number
- NCT01378325
Choroidal Thickness During Changes in Intraocular Pressure and Arterial Blood Pressure
- Conditions
- Interventions
- First Posted Date
- 2011-04-12
- Last Posted Date
- 2014-11-14
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 1
- Registration Number
- NCT01333891
- Locations
- 🇦🇹
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies
- Conditions
- Interventions
- First Posted Date
- 2011-04-11
- Last Posted Date
- 2015-06-01
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 25
- Registration Number
- NCT01332578
- Locations
- 🇬🇧
BIO-IMAGES Research Ltd., Glasgow, Scotland, United Kingdom
Effects of Phenylephrine on Nasal Congestion in Participants With Seasonal Allergic Rhinitis (P08156 AM2)(Completed)
- Conditions
- Interventions
- First Posted Date
- 2011-04-06
- Last Posted Date
- 2015-03-11
- Lead Sponsor
- Bayer
- Target Recruit Count
- 539
- Registration Number
- NCT01330017
Optimization of Hemodynamic Conditions During Caesarean Section Under Spinal Anaesthesia
- Conditions
- Interventions
- First Posted Date
- 2011-01-17
- Last Posted Date
- 2013-01-11
- Lead Sponsor
- Anestesiavdelingen Baerum Sykehus
- Target Recruit Count
- 120
- Registration Number
- NCT01278238
- Locations
- 🇳🇴
Bærum Sykehus, Rud, Akershus, Norway
Ephedrine vs Phenylephrine - ECG Changes
- Conditions
- Interventions
- First Posted Date
- 2010-11-19
- Last Posted Date
- 2016-10-26
- Lead Sponsor
- University College London Hospitals
- Target Recruit Count
- 29
- Registration Number
- NCT01243970
- Locations
- 🇬🇧
University College London Hospital, London, United Kingdom
Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
- Conditions
- Interventions
- First Posted Date
- 2010-03-04
- Last Posted Date
- 2012-05-03
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 96
- Registration Number
- NCT01080625
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Safety of Phenylephrine Hydrochloride, Acetaminophen, Dimethindene Maleate Compared to Phenylephrine Hydrochloride Alone in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2009-12-07
- Last Posted Date
- 2016-03-03
- Lead Sponsor
- Novartis
- Registration Number
- NCT01026961
- Locations
- 🇧🇷
Scentryphar Pesquisa Clinica Ltda., Campinas, São Paulo, Brazil
Role of Angiotensin II in Insulin-induced Microvascular Activity
- Conditions
- Interventions
- First Posted Date
- 2009-12-02
- Last Posted Date
- 2009-12-02
- Lead Sponsor
- Maastricht University Medical Center
- Target Recruit Count
- 18
- Registration Number
- NCT01024543
- Locations
- 🇳🇱
Maastricht University Medical Centre, Maastricht, P.o. Box 5800, Netherlands, Netherlands
Drug Development Updates
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