Phenylephrine

Generic Name: Phenylephrine

Brand Names: 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₂

CAS Number: 59-42-7

Unique Ingredient Identifier: 1WS297W6MV

Background: Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication: Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.

Associated Conditions: Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Clinical Trials

Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study

Phase 2

Completed

Conditions: Hypotension
Valve Surgery

Interventions: Drug: Placebo
Drug: Ephedrine
Drug: Phenylephrine

First Posted Date: 2009-11-03

Last Posted Date: 2020-09-02

Lead Sponsor: King Faisal University

Target Recruit Count: 150

Registration Number: NCT01006863

Locations: 🇪🇬
Mansoura University Hospitals, Mansoura, DK, Egypt
🇸🇦
King Fahd Hospital of the University, Dammam, Eastern, Saudi Arabia

Best Regimen for Phenylephrine Administration During Cesarean Section

Phase 4

Completed

Conditions: Cesarean Section
Cardiac Output
Hypotension

Interventions: Drug: Phenylephrine

First Posted Date: 2009-10-16

Last Posted Date: 2011-02-23

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 60

Registration Number: NCT00996190

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Experimental Increase of Intraocular Pressure in Healthy Humans

Not Applicable

Terminated

Conditions: Healthy

Interventions: Drug: NG-monomethyl-L-arginine (L-NMMA)
Drug: Phenylephrine
Drug: Physiological saline solution (as placebo)
Device: Laser Doppler Flowmetry
Device: Goldmann applanation tonometer
Device: Suction cup

First Posted Date: 2009-06-05

Last Posted Date: 2014-11-14

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 12

Registration Number: NCT00914394

Locations: 🇦🇹
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

Variability in Adrenergic Response

Not Applicable

Completed

Conditions: Vascular Reaction to Medications

Interventions: Drug: Phenylephrine

First Posted Date: 2009-02-06

Last Posted Date: 2018-10-26

Lead Sponsor: Vanderbilt University

Target Recruit Count: 106

Registration Number: NCT00838695

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Phenylephrine
Drug: NG-monomethyl-L-arginine (L-NMMA)
Drug: Physiological saline solution (as placebo)
Device: Laser Doppler Flowmetry
Device: Goldmann applanation tonometer
Other: squatting

First Posted Date: 2008-12-11

Last Posted Date: 2012-11-30

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 18

Registration Number: NCT00806741

Locations: 🇦🇹
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

Phenylephrine Pediatric Pharmacokinetic Study

Phase 1

Completed

Conditions: Rhinitis

Interventions: Drug: phenylephrine HCl

First Posted Date: 2008-09-30

Last Posted Date: 2011-10-06

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 36

Registration Number: NCT00762567

Locations: 🇺🇸
West Coast Clinical Trials, Cypress, California, United States

Phenylephrine in Septic Shock

Phase 2

Completed

Conditions: Septic Shock

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2008-03-19

Last Posted Date: 2017-10-26

Lead Sponsor: University of Roma La Sapienza

Target Recruit Count: 32

Registration Number: NCT00639015

Locations: 🇮🇹
Departement of Anesthesiology and Intensive Care of the University of Rome "La Sapienza" Viale del Policlinico 155, Rome, Italy

Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling

Not Applicable

Completed

Conditions: Cardiovascular Diseases

Interventions: Drug: Phenylephrine
Drug: L-NAME
Drug: L-Arginine

First Posted Date: 2008-01-29

Last Posted Date: 2018-09-12

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 54

Registration Number: NCT00603720

Locations: 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States

The Development of Tolerance to α1-Adrenoceptor Blockade With Chronic Carvedilol Treatment

Not Applicable

Completed

Conditions: Heart Failure

Interventions: Drug: phenylephrine

First Posted Date: 2008-01-03

Last Posted Date: 2012-06-13

Lead Sponsor: University of Utah

Target Recruit Count: 15

Registration Number: NCT00585091

Locations: 🇺🇸
University of Utah, Salt Lake City, Utah, United States

Phenylephrine Versus Norepinephrine in Septic Shock

Phase 2

Completed

Conditions: Septic Shock

First Posted Date: 2007-06-01

Last Posted Date: 2007-06-01

Lead Sponsor: University of Roma La Sapienza

Target Recruit Count: 15

Registration Number: NCT00481442

Locations: 🇮🇹
Department of Anesthesiology and Intensive care of the University of Rome "La Sapienza", Rome, Italy

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