Ademetionine
- Generic Name
- Ademetionine
- Drug Type
- Small Molecule
- Chemical Formula
- C15H22N6O5S
- CAS Number
- 29908-03-0
- Unique Ingredient Identifier
- 7LP2MPO46S
- Background
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
- Indication
S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.
- Associated Conditions
- Fatigue, Intrahepatic Cholestasis, Major Depressive Disorder (MDD)
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia
- Conditions
- Drug Induced Liver Injury
- Interventions
- Procedure: Plaslna exchangeProcedure: Liver transplantation
- First Posted Date
- 2025-04-10
- Last Posted Date
- 2025-04-10
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 232
- Registration Number
- NCT06922669
- Locations
- 🇨🇳
Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area), Shenyang, Liaoning, China
Metastasis-directed Therapy for Oligometastases of Breast Cancer
- Conditions
- OligometastasisMetastatic Breast CancerBreast Cancer
- Interventions
- Drug: Systemic therapy for 12 weeks after primary registrationProcedure: Radiation therapy (SBRT/conventional RT)Procedure: Surgery
- First Posted Date
- 2023-11-18
- Last Posted Date
- 2025-04-11
- Lead Sponsor
- Tokyo Medical and Dental University
- Target Recruit Count
- 340
- Registration Number
- NCT06135714
- Locations
- 🇯🇵
Tokyo Medical and Dental Univetsity, Tokyo, Japan
Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-Adenosylmethionine
- First Posted Date
- 2020-11-10
- Last Posted Date
- 2020-11-10
- Lead Sponsor
- MSI Methylation Sciences, Inc.
- Target Recruit Count
- 34
- Registration Number
- NCT04623034
Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals
- Conditions
- Adverse Drug EffectDrug EffectHeart Arrhythmia
- Interventions
- First Posted Date
- 2020-02-05
- Last Posted Date
- 2024-04-03
- Lead Sponsor
- Oslo University Hospital
- Target Recruit Count
- 10
- Registration Number
- NCT04254731
- Locations
- 🇳🇴
Department of Pharmacology , Oslo University Hospital, Oslo, Norway
🇳🇴Department of Pharmacology and Department of Substance Use Disorder, Oslo University Hospital, Oslo, Norway
🇳🇴Department of Substance Use Disorder, Oslo University Hospital, Oslo, Norway
SAMe Trial for Patients with Alcoholic Cirrhosis
- First Posted Date
- 2020-01-31
- Last Posted Date
- 2024-11-14
- Lead Sponsor
- Indiana University
- Target Recruit Count
- 196
- Registration Number
- NCT04250259
- Locations
- 🇺🇸
Cedars-Sinai Medical Center, Los Angeles, California, United States
🇺🇸Indiana University Hospital, Indianapolis, Indiana, United States
Motor-Sparing Femoral Nerve Block Dose
- Conditions
- Osteoarthritis, KneeKnee Injuries
- Interventions
- Drug: Lower Bupivacaine Concentration
- First Posted Date
- 2016-09-21
- Last Posted Date
- 2020-05-14
- Lead Sponsor
- University of Chile
- Target Recruit Count
- 31
- Registration Number
- NCT02909257
- Locations
- 🇨🇱
Hospital Clinico Universidad de Chile, Santiago, Metropolitan, Chile
Morning-Only 4 L PEG vs Split Dose Prep for Afternoon Colonoscopies, Endoscopist-Blinded Prospective Study
- Conditions
- Colonoscopy
- Interventions
- Drug: Split dose 4 L preparation (Polyethylene Glycol)
- First Posted Date
- 2015-12-31
- Last Posted Date
- 2019-12-04
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 200
- Registration Number
- NCT02643316
- Locations
- 🇺🇸
Cleveland Clinic Florida, Weston, Florida, United States
The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With Fibrosis
- Conditions
- Non-alcoholic Steatohepatitis
- Interventions
- Drug: pentoxiphylline (PTX)
- First Posted Date
- 2014-09-04
- Last Posted Date
- 2019-10-29
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 122
- Registration Number
- NCT02231333
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption
- Conditions
- Intrahepatic Cholestasis Associated With Alcoholic Liver Disease
- Interventions
- First Posted Date
- 2014-07-25
- Last Posted Date
- 2015-06-16
- Lead Sponsor
- Abbott
- Target Recruit Count
- 75
- Registration Number
- NCT02200029
- Locations
- 🇷🇺
Research facility ORG-000961, Moscow, Russian Federation
🇷🇺Research facility ORG-000967, St. Petersburg, Russian Federation
🇷🇺Research facility ORG-000966, St. Petersburg, Russian Federation
Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis
- Conditions
- Hepatitis BCholestasis
- Interventions
- First Posted Date
- 2013-12-02
- Last Posted Date
- 2014-05-29
- Lead Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
- Target Recruit Count
- 240
- Registration Number
- NCT01998620
- Locations
- 🇨🇳
Public Health Clinical Center Affiliated to Fudan University, Shanghai, Shanghai, China
Drug Development Updates
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