Azelaic acid
- Generic Name
- Azelaic acid
- Brand Names
- Azelex, Finacea
- Drug Type
- Small Molecule
- Chemical Formula
- C9H16O4
- CAS Number
- 123-99-9
- Unique Ingredient Identifier
- F2VW3D43YT
- Background
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin. Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
- Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
- Associated Conditions
- Acne Vulgaris, Inflammatory lesions caused by rosacea, Susceptible Bacterial Infections
- Associated Therapies
- Nutritional supplementation
Study to Evaluate the Feasibility of Twice Daily Use of Topical Azelaic Acid in Breast Cancer Patients Undergoing Radiation
- First Posted Date
- 2025-05-11
- Last Posted Date
- 2025-05-11
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 33
- Registration Number
- NCT06966388
- Locations
- 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States
Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)
- Conditions
- Central Centrifugal Cicatricial Alopecia
- Interventions
- Other: usual medication for CCCA
- First Posted Date
- 2022-06-13
- Last Posted Date
- 2024-08-27
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 15
- Registration Number
- NCT05416333
- Locations
- 🇺🇸
Wake Forest University Health Scieces, Winston-Salem, North Carolina, United States
Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea
- First Posted Date
- 2021-08-20
- Last Posted Date
- 2021-08-20
- Lead Sponsor
- Dermatology Specialists Research
- Target Recruit Count
- 60
- Registration Number
- NCT05014906
- Locations
- 🇺🇸
Dermatology Specialists, Louisville, Kentucky, United States
To Evaluate the Therapeutic Equivalence and Safety in Treatment of Moderate Facial Rosacea
- Conditions
- Rosacea
- Interventions
- First Posted Date
- 2018-09-28
- Last Posted Date
- 2019-03-19
- Lead Sponsor
- Taro Pharmaceuticals USA
- Target Recruit Count
- 1116
- Registration Number
- NCT03689010
- Locations
- 🇺🇸
Catawba Research, LLC, Charlotte, North Carolina, United States
A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Participants With Rosacea
- Conditions
- Rosacea
- Interventions
- Drug: Generic Azelaic Acid FoamDrug: Vehicle FoamOther: CleanserOther: SunscreenOther: TowelOther: Moisturizing Lotion
- First Posted Date
- 2017-09-19
- Last Posted Date
- 2019-07-31
- Lead Sponsor
- Actavis Inc.
- Target Recruit Count
- 924
- Registration Number
- NCT03287791
- Locations
- 🇺🇸
Investigative Site 8, High Point, North Carolina, United States
🇺🇸Investigative Site 5, Norfolk, Virginia, United States
🇺🇸Investigative Site 21, Philadelphia, Pennsylvania, United States
To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel
- Conditions
- Rosacea
- Interventions
- First Posted Date
- 2017-03-29
- Last Posted Date
- 2024-04-10
- Lead Sponsor
- Taro Pharmaceuticals USA
- Target Recruit Count
- 1000
- Registration Number
- NCT03094403
Azelaic Acid on Demodex Counts in Rosacea
- First Posted Date
- 2017-01-30
- Last Posted Date
- 2018-09-07
- Lead Sponsor
- Wake Forest University
- Target Recruit Count
- 20
- Registration Number
- NCT03035955
- Locations
- 🇺🇸
Wake Forest University Health Sciences Department of Dermatology, Winston-Salem, North Carolina, United States
Preferences & Treatment Satisfaction Drivers in Rosacea Patients
- Conditions
- Rosacea
- Interventions
- First Posted Date
- 2015-11-11
- Last Posted Date
- 2020-04-01
- Lead Sponsor
- LEO Pharma
- Target Recruit Count
- 206
- Registration Number
- NCT02602470
A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea
- First Posted Date
- 2014-04-23
- Last Posted Date
- 2020-06-02
- Lead Sponsor
- Actavis Inc.
- Target Recruit Count
- 1009
- Registration Number
- NCT02120924
- Locations
- 🇺🇸
Site 17, Glenn Dale, Maryland, United States
🇺🇸Site 6, Bay City, Michigan, United States
🇺🇸Site 24, Fremont, California, United States
Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris
- First Posted Date
- 2014-02-10
- Last Posted Date
- 2017-08-25
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 222
- Registration Number
- NCT02058628
- Locations
- 🇩🇪
GSK Investigational Site, Berlin, Germany
Drug Development Updates
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