Azelaic acid
- Generic Name
- Azelaic acid
- Brand Names
- Azelex, Finacea
- Drug Type
- Small Molecule
- Chemical Formula
- C9H16O4
- CAS Number
- 123-99-9
- Unique Ingredient Identifier
- F2VW3D43YT
- Background
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin. Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
- Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
- Associated Conditions
- Acne Vulgaris, Inflammatory lesions caused by rosacea, Susceptible Bacterial Infections
- Associated Therapies
- Nutritional supplementation
Combination Gel and Vascular ND in Mild to Moderate Rosacea
- First Posted Date
- 2012-06-29
- Last Posted Date
- 2018-09-12
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 10
- Registration Number
- NCT01631656
- Locations
- 🇺🇸
Wake Forest University Health Sciences Dept of Dermatology, Winston-Salem, North Carolina, United States
Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin
- First Posted Date
- 2011-07-04
- Last Posted Date
- 2013-07-08
- Lead Sponsor
- University of Magdeburg
- Target Recruit Count
- 60
- Registration Number
- NCT01387048
- Locations
- 🇩🇪
Clinic for Dermatology and Vereology, Central Hospital Magdeburg, Magdeburg, Saxony-Anhalt, Germany
Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular Rosacea
- Conditions
- Papulopustular Rosacea
- Interventions
- Drug: Azelaic Acid Foam
- First Posted Date
- 2010-12-10
- Last Posted Date
- 2023-06-09
- Lead Sponsor
- LEO Pharma
- Target Recruit Count
- 21
- Registration Number
- NCT01257919
- Locations
- 🇺🇸
Novum Pharmaceutical Research Services of Nevada Inc., Las Vegas, Nevada, United States
Efficacy and Safety Study of Finacea to Treat Acne Vulgaris and Post-Inflammatory Hyperpigmentation (PIH)
- Conditions
- Acne VulgarisPost Inflammatory Hyperpigmentation
- Interventions
- First Posted Date
- 2009-12-24
- Last Posted Date
- 2012-09-25
- Lead Sponsor
- Derm Research, PLLC
- Target Recruit Count
- 20
- Registration Number
- NCT01038869
- Locations
- 🇺🇸
DermResearch, PLLC, Louisville, Kentucky, United States
Azelaic Acid Versus Hydroquinone in Melasma
- First Posted Date
- 2009-06-25
- Last Posted Date
- 2009-06-25
- Lead Sponsor
- Callender Center for Clinical Research
- Target Recruit Count
- 30
- Registration Number
- NCT00927771
- Locations
- 🇺🇸
Callender Center for Clinical Research, Mitchellville, Maryland, United States
Exploration of Safety and Efficacy of AzA 15% Foam Twice a Day in Rosacea
- First Posted Date
- 2008-02-18
- Last Posted Date
- 2020-04-07
- Lead Sponsor
- LEO Pharma
- Target Recruit Count
- 83
- Registration Number
- NCT00617903
Drug Development Updates
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