Vasopressin

Generic Name: Vasopressin

Brand Names: Vasostrict

Drug Type: Small Molecule

Chemical Formula: C_₉₂H_₁₃₀N_₂₈O_₂₄S_₄

CAS Number: 11000-17-2

Unique Ingredient Identifier: Y87Y826H08

Background: Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour. Vasopressin is very similar to oxytocin, differing in the third and eighth amino acids. Despite a wide variety of functions, exogenous vaso...

Indication: 1.诊断和治疗由于缺乏抗利尿激素而引起的尿崩症，也用于其他药物效果不佳的腹部肌肉松弛；

2.脑外科手术后或头颅创伤后多尿的初期治疗；

3.用于食管、胃肠道消化道疾病的急性大出血的辅助治疗。

Associated Conditions: Acute Circulatory Failure

Associated Therapies: Dental Local Anesthesia

Clinical Trials

Methods Decreasing Bleeding in Open Myomectomy

Phase 4

Recruiting

Conditions: Oxytocin Allergy
Tranexamic Acid Allergy
Ethamsylate Allergy
Myoma
Blood Loss, Surgical
Misoprostol Allergy

Interventions: Drug: combined TXA and ethamsylate
Drug: Bupivacaine Hydrochloride 0.5 % Injectable Solution epinephrine
Device: Tourniquet
Drug: Misoprostol
Drug: Carbetocin
Drug: Oxytocin
Drug: Vasopressin

First Posted Date: 2023-04-10

Last Posted Date: 2023-04-10

Lead Sponsor: Cairo University

Target Recruit Count: 105

Registration Number: NCT05806307

Locations: 🇪🇬
faculty of medicine, Kasr el ainy hospital, Cairo university, Cairo, Egypt

Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation

Phase 1

Recruiting

Conditions: Cardiac Arrest Neonatal

Interventions: Drug: Epinephrine
Drug: Vasopressin

First Posted Date: 2023-02-21

Last Posted Date: 2023-11-30

Lead Sponsor: University of Alberta

Target Recruit Count: 20

Registration Number: NCT05738148

Locations: 🇨🇦
Royal Alexandra Hospital, Edmonton, Alberta, Canada

Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation

Phase 3

Recruiting

Conditions: Vasoplegic Syndrome
Scheduled Cardiac Surgery With Extracorporeal Circulation

Interventions: Drug: Vasopressin
Drug: Norepinephrine
Other: Collection of clinical data
Other: Quality of Life Questionnaire EQ-5D

First Posted Date: 2022-10-05

Last Posted Date: 2023-09-08

Lead Sponsor: Centre Hospitalier Universitaire Dijon

Target Recruit Count: 840

Registration Number: NCT05568160

Locations: 🇫🇷
Chu Dijon Bourgogne, Dijon, France

Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial

Not Applicable

Conditions: Septic Shock
Cirrhosis, Liver

Interventions: Drug: Terlipressin
Drug: vasopressin

First Posted Date: 2022-04-07

Last Posted Date: 2022-04-07

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 100

Registration Number: NCT05315557

Locations: 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India

Angiotensin II vs. Vasopressin in Septic Shock

Phase 4

Withdrawn

Conditions: Septic Shock

Interventions: Drug: Angiotensin II
Drug: Vasopressin

First Posted Date: 2022-01-14

Last Posted Date: 2024-03-15

Lead Sponsor: University of New Mexico

Registration Number: NCT05193370

Locations: 🇺🇸
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States

Effects of Oxytocin and Vasopressin on Moral Decision Making

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Placebo
Drug: Vasopressin
Drug: Oxytocin

First Posted Date: 2021-05-18

Last Posted Date: 2023-09-21

Lead Sponsor: University of Electronic Science and Technology of China

Target Recruit Count: 180

Registration Number: NCT04890470

Locations: 🇨🇳
Xiaoxiao Zheng, Sichuan, Sichuan, China

Comparison of Concentration of Vasopressin During Robot-assisted Laparoscopic Myomectomy

Not Applicable

Completed

Conditions: Uterine Leiomyoma

Interventions: Drug: Vasopressin

First Posted Date: 2021-05-05

Last Posted Date: 2023-06-26

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 39

Registration Number: NCT04874246

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Differential Effects of Vasopressin and Oxytocin on Attention Control

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Placebo
Drug: Vasopressin
Drug: Oxytocin

First Posted Date: 2021-01-20

Last Posted Date: 2021-01-22

Lead Sponsor: University of Electronic Science and Technology of China

Target Recruit Count: 160

Registration Number: NCT04715737

Locations: 🇨🇳
University of Electronic Science and Technology of China (UESTC), Sichuan, Chengdu, China

Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery

Phase 4

Recruiting

Conditions: Acute Kidney Injury

Interventions: Drug: Vasopressin
Drug: Phenylephrine

First Posted Date: 2020-10-26

Last Posted Date: 2024-03-29

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 300

Registration Number: NCT04602767

Locations: 🇺🇸
Thomas Jefferson Univesity, Philadelphia, Pennsylvania, United States

Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

Phase 3

Active, not recruiting

Conditions: Cardiac Disease

Interventions: Drug: Norepinephrine
Drug: Vasopressin

First Posted Date: 2020-08-06

Last Posted Date: 2024-02-09

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 160

Registration Number: NCT04501861

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

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