Sodium bicarbonate
- Generic Name
- Sodium bicarbonate
- Brand Names
- Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide
- Drug Type
- Small Molecule
- Chemical Formula
- CHNaO3
- CAS Number
- 144-55-8
- Unique Ingredient Identifier
- 8MDF5V39QO
- Background
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
- Indication
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significan...
- Associated Conditions
- Barbiturate intoxication, Breast Cancer, Constipation, Dental Decay, Duodenal Ulcer, Dyspepsia, Gastro-esophageal Reflux Disease (GERD), Gingival Bleeding, Heartburn, Helicobacter Infections, Hyperkalemia, Ischaemia, Metabolic Acidosis, Myocardial Infarction, Plaque, Dental, Pruritis of the skin, Skin Irritation, Upper GI Bleeding, Upset stomach, Zollinger-Ellison Syndrome, Abdominal bloating, Benign, active Gastric Ulcer, Methyl alcohol poisoning, Prophylaxis of Contrast-induced nephropathy, Salicylate poisoning, Severe Diarrhea, Swelling of the gums
- Associated Therapies
- Bowel preparation therapy
Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
- Conditions
- Interventions
- First Posted Date
- 2014-01-09
- Last Posted Date
- 2020-09-22
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 20
- Registration Number
- NCT02031770
- Locations
- 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States
The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
- First Posted Date
- 2013-08-09
- Last Posted Date
- 2018-07-17
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 70
- Registration Number
- NCT01920126
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
- Conditions
- Interventions
- First Posted Date
- 2013-07-10
- Last Posted Date
- 2019-03-20
- Lead Sponsor
- University Hospitals Cleveland Medical Center
- Target Recruit Count
- 7
- Registration Number
- NCT01894594
- Locations
- 🇺🇸
University hospitals Case Medical Center, Cleveland, Ohio, United States
Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain
- Conditions
- Interventions
- First Posted Date
- 2013-05-03
- Last Posted Date
- 2015-06-04
- Target Recruit Count
- 9
- Registration Number
- NCT01846429
- Locations
- 🇺🇸
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)
- Conditions
- Interventions
- First Posted Date
- 2013-04-25
- Last Posted Date
- 2017-10-27
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 162
- Registration Number
- NCT01840241
- Locations
- 🇰🇷
Department of anesthesiology and pain medicine, Seoul, Korea, Republic of
A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions
- Conditions
- Interventions
- First Posted Date
- 2012-10-19
- Last Posted Date
- 2012-10-19
- Lead Sponsor
- Norgine
- Target Recruit Count
- 20
- Registration Number
- NCT01710995
- Locations
- 🇬🇧
Bio-Kinetic Europe Limited, 14 Great Victoria Street, Belfast BT2 7BA, Belfast, United Kingdom
Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
- First Posted Date
- 2012-06-19
- Last Posted Date
- 2014-03-17
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 20
- Registration Number
- NCT01622296
- Locations
- 🇺🇸
University of California, San Francisco, San Francisco, California, United States
Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.
- Conditions
- Interventions
- First Posted Date
- 2012-04-10
- Last Posted Date
- 2019-08-28
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 74
- Registration Number
- NCT01574157
- Locations
- 🇺🇸
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah, United States
Phase III Study Comparing Zegerid® With Losec® for the Relief of Heartburn Associated With Gastroesophageal Reflux Disease
- First Posted Date
- 2011-12-15
- Last Posted Date
- 2013-08-13
- Lead Sponsor
- Norgine
- Target Recruit Count
- 239
- Registration Number
- NCT01493089
- Locations
- 🇵🇱
Department of Gastroenterology and Hepatology, Oncology Centre, Roentgena, Warsaw, Poland
Alkali Therapy in Chronic Kidney Disease
- Conditions
- Interventions
- First Posted Date
- 2011-10-14
- Last Posted Date
- 2020-01-07
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 149
- Registration Number
- NCT01452412
- Locations
- 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
🇺🇸Albert Einstein College of Medicine, Bronx, New York, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.