Sodium bicarbonate

Generic Name: Sodium bicarbonate

Brand Names: Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide

Drug Type: Small Molecule

Chemical Formula: CHNaO_₃

CAS Number: 144-55-8

Unique Ingredient Identifier: 8MDF5V39QO

Background: Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Indication: Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.

Associated Conditions: Barbiturate intoxication, Breast Cancer, Constipation, Dental Decay, Duodenal Ulcer, Dyspepsia, Gastro-esophageal Reflux Disease (GERD), Gingival Bleeding, Heartburn, Helicobacter Infections, Hyperkalemia, Ischaemia, Metabolic Acidosis, Myocardial Infarction, Plaque, Dental, Pruritis of the skin, Skin Irritation, Upper GI Bleeding, Upset stomach, Zollinger-Ellison Syndrome, Abdominal bloating, Benign, active Gastric Ulcer, Methyl alcohol poisoning, Prophylaxis of Contrast-induced nephropathy, Salicylate poisoning, Severe Diarrhea, Swelling of the gums

Associated Therapies: Bowel preparation therapy

Clinical Trials

Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis

Phase 3

Completed

Conditions: Local Anesthesia

Interventions: Drug: sodium bicarbonate
Drug: placebo

First Posted Date: 2014-08-27

Last Posted Date: 2016-08-31

Lead Sponsor: Masoud Saatchi

Target Recruit Count: 80

Registration Number: NCT02226913

Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery

Phase 2

Terminated

Conditions: Acute Kidney Injury
Congenital Heart Disease

Interventions: Drug: Sodium Bicarbonate
Drug: Sodium Chloride

First Posted Date: 2014-01-27

Last Posted Date: 2022-11-02

Lead Sponsor: Northwell Health

Target Recruit Count: 51

Registration Number: NCT02046135

Locations: 🇺🇸
Cohen Children's Medical Center of New York, New Hyde Park, New York, United States

Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease

Not Applicable

Completed

Conditions: Metabolic Acidosis
Chronic Kidney Disease

Interventions: Drug: Sodium bicarbonate
Other: Control

First Posted Date: 2014-01-09

Last Posted Date: 2020-09-22

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 20

Registration Number: NCT02031770

Locations: 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States

The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery

Phase 4

Completed

Conditions: Acute Kidney Injury

Interventions: Drug: Saline
Drug: sodium bicarbonate

First Posted Date: 2013-08-09

Last Posted Date: 2018-07-17

Lead Sponsor: Yonsei University

Target Recruit Count: 70

Registration Number: NCT01920126

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease

Phase 1

Terminated

Conditions: Metabolic Acidosis
Chronic Kidney Disease
Sickle Cell Anemia

Interventions: Drug: Sodium Bicarbonate

First Posted Date: 2013-07-10

Last Posted Date: 2019-03-20

Lead Sponsor: University Hospitals Cleveland Medical Center

Target Recruit Count: 7

Registration Number: NCT01894594

Locations: 🇺🇸
University hospitals Case Medical Center, Cleveland, Ohio, United States

Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain

Phase 1

Terminated

Conditions: Pain
Unresectable Malignant Neoplasm
Lymphoma
Cancer
Tumor
Malignant Solid Tumor
Neoplasm Metastasis
Hematologic Malignancy
Multiple Myeloma