Sevoflurane
- Generic Name
- Sevoflurane
- Brand Names
- Sevorane, Sojourn, Ultane
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3F7O
- CAS Number
- 28523-86-6
- Unique Ingredient Identifier
- 38LVP0K73A
- Background
Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.
- Indication
Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
- Associated Conditions
- -
- Associated Therapies
- General Anesthesia, Induction and Maintenance of General Anesthesia
Comparison of Optic Nerve Sheath Diameter in Children Receiving Caudal Block According to Anesthetic Agents: Total Intravenous Anesthesia vs. Volatile Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2020-06-04
- Last Posted Date
- 2022-05-05
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 60
- Registration Number
- NCT04415905
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
Comparison Between Two Types of Sedation for Elective Upper Endoscopy Procedures
- Conditions
- Interventions
- First Posted Date
- 2020-06-01
- Last Posted Date
- 2020-06-01
- Lead Sponsor
- University of Malaya
- Target Recruit Count
- 30
- Registration Number
- NCT04410211
- Locations
- 🇲🇾
University Malaya Medical Centre, Kuala Lumpur, WP Kuala Lumpur, Malaysia
Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in Children
- Conditions
- Interventions
- First Posted Date
- 2020-04-28
- Last Posted Date
- 2024-11-19
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT04364945
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Other, Korea, Republic of
Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection
- Conditions
- Interventions
- First Posted Date
- 2020-04-24
- Last Posted Date
- 2021-07-27
- Target Recruit Count
- 19
- Registration Number
- NCT04359862
- Locations
- 🇪🇸
Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain
🇪🇸Hospital Universitario Ramón y Cajal, Madrid, Spain
🇪🇸Hospital Clínico Universitario de Valencia, Valencia, Spain
Sevoflurane in COVID-19 ARDS (SevCov)
- Conditions
- Interventions
- First Posted Date
- 2020-04-21
- Last Posted Date
- 2021-07-19
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 68
- Registration Number
- NCT04355962
- Locations
- 🇨🇭
Kantonsspital Münsterlingen, Münsterlingen, Switzerland
🇨🇭University Hospital Zuirch, Zurich, Switzerland
🇨🇭Stadtspital Triemli, Zurich, Switzerland
Sevoflurane and Success of External Cephalic Version (ECV)
- First Posted Date
- 2020-04-15
- Last Posted Date
- 2020-04-24
- Lead Sponsor
- King Saud University
- Target Recruit Count
- 40
- Registration Number
- NCT04346823
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial
- Conditions
- Interventions
- First Posted Date
- 2020-03-20
- Last Posted Date
- 2023-03-23
- Lead Sponsor
- Peter MacCallum Cancer Centre, Australia
- Target Recruit Count
- 3500
- Registration Number
- NCT04316013
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
🇦🇺Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
🇦🇺RedCliffe Hospital, Redcliffe, Queensland, Australia
Namsos Anaesthesia Children Outcome Study
- First Posted Date
- 2020-03-03
- Last Posted Date
- 2024-03-01
- Lead Sponsor
- Helse Nord-Trøndelag HF
- Target Recruit Count
- 761
- Registration Number
- NCT04292457
- Locations
- 🇳🇴
ØNH Legen, Trondheim, Trøndelag, Norway
🇳🇴Namsos Hospital, Nord-Trondelag Hospital Trust, Namsos, Trøndelag, Norway
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R
- Conditions
- Interventions
- First Posted Date
- 2020-02-27
- Last Posted Date
- 2020-02-27
- Lead Sponsor
- Negovsky Reanimatology Research Institute
- Registration Number
- NCT04287842
Anesthesia and Cancer Study: Colon Cancer
- Conditions
- Interventions
- First Posted Date
- 2020-02-06
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 797
- Registration Number
- NCT04259398
- Locations
- 🇰🇷
Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea, Republic of
🇰🇷Seoul National University Hospital, Seoul, Korea, Republic of
Drug Development Updates
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