Inositol is a collection of nine different stereoisomers but the name is usually used to describe only the most common type of inositol, myo-inositol. Myo-inositol is the cis-1,2,3,5-trans-4,6-cyclohexanehexol and it is prepared from an aqueous extract of corn kernels by precipitation and hydrolysis of crude phytate. These molecules have structural similarities to glucose and are involved in cellular signaling. It is considered a pseudovitamin as it is a molecule that does not qualify to be an essential vitamin because even though its presence is vital in the body, a deficiency in this molecule does not translate into disease conditions. Inositol can be found as an ingredient of OTC products by Health Canada but all current product whose main ingredient is inositol are discontinued. By the FDA, inositol is considered in the list of specific substances affirmed as generally recognized as safe (GRAS).
Inositol may be used in food without any limitation. As a drug, inositol is used as a nutrient supplement in special dietary foods and infant formula. As it presents a relevant role in ensuring oocyte fertility, inositol has been studied for its use in the management of polycystic ovaries. Inositol is also being researched for the treatment of diabetes, prevention of metabolic syndrome, aid agent for weight loss, treatment of depression, psychiatric disorder and anxiety disorder and for prevention of cancer.
University of California - Los Angeles, Los Angeles, California, United States
Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States
University of Chicago, Chicago, Illinois, United States
Universitร cattolica S. Cuore, Rome, Italy
Catholic University of Sacred Heart, Rome, Italy
Massachusetts General Hospital, Boston, Massachusetts, United States
University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States
Mount Sinai Medical Center, New York, New York, United States
Northwestern University, Chicago, Illinois, United States
University of Iowa, Iowa City, Iowa, United States
Stanford University, Palo Alto, California, United States
Emory University, Atlanta, Georgia, United States
Mayo Clinic in Arizona, Scottsdale, Arizona, United States
Mayo Clinic, Rochester, Minnesota, United States
Albuquerque Veterans Administration Medical Center, Albuquerque, New Mexico, United States
Indiana University, Indianapolis, Indiana, United States
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States
Duke University, Durham, North Carolina, United States
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