Ganciclovir
- Generic Name
- Ganciclovir
- Brand Names
- Cytovene, Zirgan
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13N5O4
- CAS Number
- 82410-32-0
- Unique Ingredient Identifier
- P9G3CKZ4P5
- Background
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
- Indication
For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients.
- Associated Conditions
- CMV colitis, Cytomegalovirus (CMV) Infections, Cytomegalovirus Retinitis, Cytomegalovirus gastroesophagitis, Varicella-zoster Progressive outer retinal necrosis, Acute Herpetic keratitis, Cytomegalovirus neurological disease, Varicella-zoster virus acute retinal necrosis
Kinetics of Response of Cytomegalovirus With Ganciclovir Treatment Using Quantitative Real-Time PCR
- Conditions
- Cytomegalovirus Infections
- First Posted Date
- 2000-02-21
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Registration Number
- NCT00004573
- Locations
- 🇺🇸
Infectious Diseases Division, St. Louis, Missouri, United States
Gene Therapy for the Treatment of Brain Tumors
- Conditions
- Brain NeoplasmNeoplasm Metastasis
- First Posted Date
- 1999-11-04
- Last Posted Date
- 2017-07-02
- Target Recruit Count
- 15
- Registration Number
- NCT00001328
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection
- Conditions
- Cytomegalovirus Infections
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 130
- Registration Number
- NCT00004278
Studies of the Ocular Complications of AIDS (SOCA)--Cytomegalovirus Retinitis Retreatment Trial (CRRT)
- Conditions
- HIV InfectionsAcquired Immunodeficiency SyndromeCytomegalovirus Retinitis
- Interventions
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2015-09-14
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 279
- Registration Number
- NCT00000134
Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT)
- Conditions
- HIV InfectionsCytomegalovirus Retinitis
- Interventions
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2015-10-22
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 234
- Registration Number
- NCT00000136
Drug Development Updates
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