Nifedipine

Generic Name
Nifedipine
Brand Names
Adalat, Afeditab CR, Nifediac, Nifedical, Procardia
Drug Type
Small Molecule
Chemical Formula
C17H18N2O6
CAS Number
21829-25-4
Unique Ingredient Identifier
I9ZF7L6G2L
Background

Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972. Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and lo...

Indication

Nifedipine capsules are indicated to treat vasospastic angina and chronic stable angina. Extended release tablets are indicated to treat vasospastic angina, chronic stable angina, and hypertension.

Associated Conditions
Achalasia, Chronic Stable Angina Pectoris, Fissure;Anal, Hypertension, Hypertensive Emergency, Premature Labour, Proctalgia, Pulmonary Edemas, Pulmonary Hypertension (PH), Raynaud's Phenomenon, Ureteral Calculus, Vasospastic Angina
Associated Therapies
-
Clinical Trials
Related News

Individualized Dosing of Nifedipine For Tocolysis in Preterm Labor

Completed
Conditions
Preterm Labor
Interventions
Drug: Nifedipine
First Posted Date
2014-03-18
Last Posted Date
2019-06-26
Lead Sponsor
Indiana University
Target Recruit Count
20
Registration Number
NCT02090920
Locations
🇺🇸

Eskenazi Health, Indianapolis, Indiana, United States

🇺🇸

IU Health Methodist, Indianapolis, Indiana, United States

Nifedipine Treatment on Uterine Contractility in IVF

Phase 2
Conditions
Embryo Implantation
Interventions
Drug: Nifedipine
First Posted Date
2014-02-26
Last Posted Date
2017-03-01
Lead Sponsor
Hadassah Medical Organization
Target Recruit Count
90
Registration Number
NCT02072291
Locations
🇮🇱

Hadassah Medical Organization, Jerusalem, Israel

Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour

Phase 4
Conditions
Preterm Labor
Interventions
Drug: Nifedipine
First Posted Date
2014-02-21
Last Posted Date
2015-07-28
Lead Sponsor
Chantal Csajka
Target Recruit Count
75
Registration Number
NCT02068404
Locations
🇨🇭

Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud, Switzerland

Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial

Phase 2
Conditions
Preterm Labor
Interventions
Drug: utrogestan
Drug: Nifedipine
First Posted Date
2013-11-15
Last Posted Date
2013-11-15
Lead Sponsor
nor zila hassan malek
Target Recruit Count
32
Registration Number
NCT01985594
Locations
🇲🇾

Obstetric and Gynaecology Department, National University of Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia

Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy

First Posted Date
2013-07-31
Last Posted Date
2018-11-08
Lead Sponsor
Gynuity Health Projects
Target Recruit Count
894
Registration Number
NCT01912677
Locations
🇮🇳

Daga Women's Hospital, Nagpur, Maharashtra, India

🇮🇳

Government Medical College, Nagpur, Maharashtra, India

HIGH Altitude CArdiovascular REsearch in the ANDES

First Posted Date
2013-04-12
Last Posted Date
2013-04-12
Lead Sponsor
Istituto Auxologico Italiano
Target Recruit Count
100
Registration Number
NCT01830530
Locations
🇵🇪

Universidad Peruana Cayetano Heredia, Lima, Peru

A Study Examining the Use of Vaginal Nifedipine With Pelvic Floor Physical Therapy for Levator Myalgia and Pelvic Pain

Not Applicable
Withdrawn
Conditions
Levator Ani Syndrome
Interventions
Drug: Placebo Ointment Base
Drug: Nifedipine
First Posted Date
2012-04-26
Last Posted Date
2014-05-22
Lead Sponsor
Vanderbilt University
Registration Number
NCT01586286
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Nifedipine Versus Indomethacin in the Treatment of Preterm Labour

First Posted Date
2011-05-25
Last Posted Date
2015-01-05
Lead Sponsor
Saint Thomas Hospital, Panama
Target Recruit Count
216
Registration Number
NCT01360034
Locations
🇵🇦

Saint Thomas Hospital, Panama, Panama

Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia

Not Applicable
Completed
Conditions
Pre-Eclampsia
Pregnancy
Hypertension
Interventions
Drug: Nifedipine
First Posted Date
2011-05-10
Last Posted Date
2012-11-12
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
20
Registration Number
NCT01351428
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Nifedipine Treatment in Preterm Labor

Phase 3
Withdrawn
Conditions
Threatened Preterm Labor
Interventions
Drug: Nifedipine
Drug: Atosiban
First Posted Date
2011-03-15
Last Posted Date
2014-07-29
Lead Sponsor
Hospital Clinico Universitario de Santiago
Registration Number
NCT01314859
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