Nifedipine

Generic Name: Nifedipine

Brand Names: Adalat, Afeditab CR, Nifediac, Nifedical, Procardia

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₈N_₂O_₆

CAS Number: 21829-25-4

Unique Ingredient Identifier: I9ZF7L6G2L

Background: Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972. Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and lo...

Indication: Nifedipine capsules are indicated to treat vasospastic angina and chronic stable angina. Extended release tablets are indicated to treat vasospastic angina, chronic stable angina, and hypertension.

Associated Conditions: Achalasia, Chronic Stable Angina Pectoris, Fissure;Anal, Hypertension, Hypertensive Emergency, Premature Labour, Proctalgia, Pulmonary Edemas, Pulmonary Hypertension (PH), Raynaud's Phenomenon, Ureteral Calculus, Vasospastic Angina

Associated Therapies: -

Clinical Trials

Transdermal Nitroglycerin and Nifedipine in Preterm Labor

Phase 4

Completed

Conditions: Managing Preterm Labor

Interventions: Drug: Transdermal nitroglycerin
Drug: nifedipine

First Posted Date: 2015-10-22

Last Posted Date: 2015-10-22

Lead Sponsor: Shiraz University of Medical Sciences

Target Recruit Count: 112

Registration Number: NCT02583633

The Effects of Doxazosin and Nifedipine on Blood Pressure Variability and Uric Acid in Plasma in Hypertensive Patients

Phase 2

Conditions: Hypertension

Interventions: Drug: Doxazosin
Drug: Nifedipine

First Posted Date: 2015-09-30

Last Posted Date: 2016-07-28

Lead Sponsor: First Affiliated Hospital of Harbin Medical University

Target Recruit Count: 30

Registration Number: NCT02563405

Locations: 🇨🇳
uric acid test and 24-hour ambulatory BP monitoring, Harbin, Heilongjiang, China

Early Vascular Adjustments During Hypertensive Pregnancy

Phase 4

Conditions: Hypertension, Pregnancy-Induced
Pre-Eclampsia

Interventions: Drug: Labetalol
Drug: Nifedipine
Drug: Methyldopa

First Posted Date: 2015-08-24

Last Posted Date: 2021-03-24

Lead Sponsor: Maastricht University Medical Center

Target Recruit Count: 368

Registration Number: NCT02531490

Locations: 🇳🇱
Maastricht UMC, Maastricht, Netherlands

The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure

Phase 2

Completed

Conditions: Chronic Anal Fissure

Interventions: Drug: Nifedipine

First Posted Date: 2015-08-18

Last Posted Date: 2018-10-23

Lead Sponsor: RDD Pharma Ltd

Target Recruit Count: 339

Registration Number: NCT02527109

Locations: 🇧🇬
MC Health BG EOOD, Sofia, Bulgaria
🇧🇬
MC "New rehabilitation centre'' EOOD, Stara Zagora, Bulgaria
🇧🇬
"Multiprofile Regional Hospital for Active Treatment - Dr. St. Cherkezov" AD Department of Gastroenterology, Veliko Tarnovo, Bulgaria

and more 21 locations

The Effects of Nifedipine and Metoprolol on Blood Pressure Variability in Northern Chinese

Phase 2

Conditions: Hypertension

Interventions: Drug: metoprolol
Drug: Nifedipine

First Posted Date: 2015-08-03

Last Posted Date: 2015-09-30

Lead Sponsor: First Affiliated Hospital of Harbin Medical University

Target Recruit Count: 40

Registration Number: NCT02513927

Locations: 🇭🇺
Twenty-four-hour ambulatory BP monitoring, Budapest, Hungary

Nifedipine or Nifedipine Plus Indomethacin for Treatment of Acute Preterm Labor

Phase 4

Terminated

Conditions: Preterm Labor

Interventions: Drug: Nifedipine
Drug: Indomethacin

First Posted Date: 2015-05-08

Last Posted Date: 2021-11-24

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 49

Registration Number: NCT02438371

Locations: 🇺🇸
Memorial Hermann Hospital Texas Medical Center, Houston, Texas, United States

Comparison of Tab.Labetalol and Tab.Nifedipine for Management of Postpartum Hypertension

Phase 3

Conditions: Postnatal Hypertension

Interventions: Drug: Labetalol
Drug: Nifedipine

First Posted Date: 2015-04-24

Last Posted Date: 2015-04-24

Lead Sponsor: Dow University of Health Sciences

Target Recruit Count: 98

Registration Number: NCT02426177

Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Early Morning Blood Pressure and Central Arterial Pressure

Phase 4

Conditions: Essential Hypertension

Interventions: Drug: nifedipine CR tablets (Xin Ran)
Drug: Adalat

First Posted Date: 2015-02-06

Last Posted Date: 2015-02-06

Lead Sponsor: Shanghai Shyndec Pharmaceutical Co., Ltd.

Target Recruit Count: 244

Registration Number: NCT02357615

Locations: 🇨🇳
Ruijin Hospital Affiliated to Shanghai Jiao Tong University Medical School, Shanghai, China

Oral Nifedipine Versus Oral Labetalol

Not Applicable

Completed

Conditions: Severe Postpartum Hypertension

Interventions: Drug: Nifedipine
Drug: Labetalol

First Posted Date: 2014-06-20

Last Posted Date: 2017-12-13

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 50

Registration Number: NCT02168309

Locations: 🇺🇸
Cedars Sinai Medical Center, Los Angeles, California, United States

Nifedipine for Acute Tocolysis of Preterm Labor

Phase 3

Completed

Conditions: Preterm Labor

Interventions: Drug: Placebo
Drug: Nifedipine
Other: Usual care

First Posted Date: 2014-05-07

Last Posted Date: 2020-12-21

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 88

Registration Number: NCT02132533

Locations: 🇺🇸
Parkland Memorial Hospital, Dallas, Texas, United States

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