Nifedipine

Generic Name: Nifedipine

Brand Names: Adalat, Afeditab CR, Nifediac, Nifedical, Procardia

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₈N_₂O_₆

CAS Number: 21829-25-4

Unique Ingredient Identifier: I9ZF7L6G2L

Background: Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972. Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer durations of action. The most popular of the third generation dihydropyridines is amlodipine.

Nifedipine was granted FDA approval on 31 December 1981.

Indication: Nifedipine capsules are indicated to treat vasospastic angina and chronic stable angina. Extended release tablets are indicated to treat vasospastic angina, chronic stable angina, and hypertension.

Associated Conditions: Achalasia, Chronic Stable Angina Pectoris, Fissure;Anal, Hypertension, Hypertensive Emergency, Premature Labour, Proctalgia, Pulmonary Edemas, Pulmonary Hypertension (PH), Raynaud's Phenomenon, Ureteral Calculus, Vasospastic Angina

Clinical Trials

Nifedipine Versus Magnesium Sulfate for Late Preterm Tocolysis

Not Applicable

Recruiting

Conditions: Threatened Preterm Labor

Interventions: Drug: Magnesium Sulfate
Drug: Nifedipine 20 Mg

First Posted Date: 2022-04-25

Last Posted Date: 2023-12-08

Lead Sponsor: Assiut University

Target Recruit Count: 264

Registration Number: NCT05343806

Locations: 🇪🇬
Faculty of Medicine, Assiut University, Assiut, Egypt

Nifedipine Plus Magnesium Sulfate Versus Magnesium Sulfate for Very Early Preterm Tocolysifs

Not Applicable

Recruiting

Conditions: Threatened Preterm Labor

Interventions: Drug: Nifedipine 20 Mg
Drug: Magnesium sulfate

First Posted Date: 2022-04-25

Last Posted Date: 2023-12-08

Lead Sponsor: Assiut University

Target Recruit Count: 264

Registration Number: NCT05345132

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial

Phase 4

Recruiting

Conditions: Hypertension in Pregnancy
Postpartum Preeclampsia

Interventions: Drug: NIFEdipine ER
Drug: Labetalol Oral Tablet

First Posted Date: 2022-04-04

Last Posted Date: 2024-04-12

Lead Sponsor: Nebraska Methodist Health System

Target Recruit Count: 600

Registration Number: NCT05309460

Locations: 🇺🇸
Nebraska Methodist Women's Hospital, Omaha, Nebraska, United States

Postpartum Hypertension Study

Phase 4

Recruiting

Conditions: Postpartum Pregnancy-Induced Hypertension
Postpartum Preeclampsia
Pregnancy-Induced Hypertension in Postpartum
Hypertensive Emergency

Interventions: Drug: Labetalol
Drug: Nifedipine

First Posted Date: 2021-12-01

Last Posted Date: 2025-04-01

Lead Sponsor: Columbia University

Target Recruit Count: 104

Registration Number: NCT05139238

Locations: 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States

Nifedipine Dosing Daily vs Twice a Day for Pre-eclampsia With Severe Features (NOPPI)

Completed

Conditions: Preeclampsia With Severe Features

Interventions: Drug: Nifedipine XL

First Posted Date: 2021-10-27

Last Posted Date: 2023-12-22

Lead Sponsor: Ohio State University

Target Recruit Count: 56

Registration Number: NCT05096728

Locations: 🇺🇸
The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio, United States

Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension

Phase 4

Active, not recruiting

Conditions: Postpartum Preeclampsia
Hypertension in Pregnancy

Interventions: Drug: ACE Inhibitors and Diuretics
Drug: NIFEdipine ER

First Posted Date: 2021-09-20

Last Posted Date: 2023-08-14

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 70

Registration Number: NCT05049616

Locations: 🇺🇸
University of Texas Health Science Center, Houston, Texas, United States

Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension

Phase 4

Completed

Conditions: Hypertension in Pregnancy

Interventions: Drug: Amlodipine
Drug: NIFEdipine ER

First Posted Date: 2021-03-10

Last Posted Date: 2024-10-28

Lead Sponsor: Prisma Health-Upstate

Target Recruit Count: 175

Registration Number: NCT04790279

Locations: 🇺🇸
Greenville Memorial Hospital, Greenville, South Carolina, United States

Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy

Recruiting

Conditions: Diastolic Hypertension
Cardiac Output, High
Cardiac Output, Low
Pregnancy Related
Systolic Hypertension

Interventions: Drug: Nifedipine
Drug: Labetalol
Drug: Atenolol

First Posted Date: 2021-02-16

Last Posted Date: 2025-05-13

Lead Sponsor: Marshall University

Target Recruit Count: 60

Registration Number: NCT04755764

Locations: 🇺🇸
Maternal Hypertension Center at Cabell Huntington Hospital, Huntington, West Virginia, United States

The Efficacy of Nifedipine in the Management of Preterm Labor

Conditions: Preterm Labor With Preterm Delivery in Third Trimester
Side Effect of Drug
Preterm Labor
Preterm Birth
Calcium-Channel Blockers Toxicity
Preterm Labor Without Delivery