Clobazam
- Generic Name
- Clobazam
- Brand Names
- Onfi, Sympazan
- Drug Type
- Small Molecule
- Chemical Formula
- C16H13ClN2O2
- CAS Number
- 22316-47-8
- Unique Ingredient Identifier
- 2MRO291B4U
- Background
Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike older 1,4-benzodiazepines, clobazam has a b...
- Indication
Clobazam is indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older.
- Associated Conditions
- Anxiety, Catamenial Epilepsy, Refractory Status Epilepticus, Seizures, Status Epilepticus
- Associated Therapies
- -
Clobazam Use in Epilepsia Partialis Continua - Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2014-05-09
- Last Posted Date
- 2018-05-09
- Lead Sponsor
- The Cooper Health System
- Target Recruit Count
- 7
- Registration Number
- NCT02134366
- Locations
- 🇺🇸
Cooper Universtiy Hospital, Camden, New Jersey, United States
GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation
- Conditions
- Interventions
- First Posted Date
- 2011-02-08
- Last Posted Date
- 2011-12-14
- Lead Sponsor
- University Hospital, Geneva
- Target Recruit Count
- 25
- Registration Number
- NCT01291316
- Locations
- 🇨🇭
University Hospitals, Geneva, Switzerland
Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain (Predictio)
- Conditions
- Interventions
- First Posted Date
- 2010-08-11
- Last Posted Date
- 2016-04-06
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 150
- Registration Number
- NCT01179828
- Locations
- 🇨🇭
Andreas Siegenthaler, Dep. of Anesthesiolgy and Pain therapy, Bern University Hospital, Switzerland
Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrome
- First Posted Date
- 2010-07-12
- Last Posted Date
- 2018-03-21
- Lead Sponsor
- Lundbeck LLC
- Target Recruit Count
- 267
- Registration Number
- NCT01160770
Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers
- First Posted Date
- 2009-11-11
- Last Posted Date
- 2010-08-11
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 17
- Registration Number
- NCT01011036
- Locations
- 🇨🇭
Dep of Anesthesiology and Pain Therapy, University Hospital Bern, Bern, Switzerland
Drug Development Updates
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