Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
Drug-Drug Interaction Study Assessing Effect of Itraconazole on PF-07321332/Ritonavir in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2021-07-14
- Last Posted Date
- 2023-07-13
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 12
- Registration Number
- NCT04962022
- Locations
- 🇧🇪
Brussels Clinical Research Unit, Brussels, Bruxelles-capitale, Région DE, Belgium
A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib
- Conditions
- Interventions
- First Posted Date
- 2021-07-13
- Last Posted Date
- 2022-09-16
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 5
- Registration Number
- NCT04959266
- Locations
- 🇪🇸
Research Site, Malaga, Spain
A Study to Assess the Effect of Itraconazole, Phenytoin and Gemfibrozil on the Drug Levels of BMS-986166 in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2021-07-09
- Last Posted Date
- 2022-05-13
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 15
- Registration Number
- NCT04956627
- Locations
- 🇺🇸
Hassman Research Institute, Berlin, New Jersey, United States
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of KRP-A218 in Healthy Subjects
- First Posted Date
- 2021-06-01
- Last Posted Date
- 2024-01-08
- Lead Sponsor
- Kyorin Pharmaceutical Co.,Ltd
- Target Recruit Count
- 99
- Registration Number
- NCT04908800
- Locations
- 🇬🇧
Labcorp Clinical Research, Leeds, United Kingdom
A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, Food Effects, and Drug-drug Interactions of ACP-196 in Healthy Participants
- First Posted Date
- 2021-05-26
- Last Posted Date
- 2021-05-26
- Lead Sponsor
- Acerta Pharma BV
- Target Recruit Count
- 59
- Registration Number
- NCT04901923
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
DDI Study of ASC41 in HV and the PK, Safety and Tolerability in Subjects With NAFLD.
- First Posted Date
- 2021-04-15
- Last Posted Date
- 2021-07-19
- Lead Sponsor
- Gannex Pharma Co., Ltd.
- Target Recruit Count
- 24
- Registration Number
- NCT04845646
- Locations
- 🇺🇸
ICON early Phase Services LLC, San Antonio, Texas, United States
Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects
- First Posted Date
- 2021-04-13
- Last Posted Date
- 2021-08-23
- Lead Sponsor
- Ascletis Pharmaceuticals Co., Ltd.
- Target Recruit Count
- 24
- Registration Number
- NCT04843449
- Locations
- 🇨🇳
Hunan provincial people's hospital, Changsha, Hunan, China
A Study of LY3484356 in Healthy Female Participants
- Conditions
- Interventions
- First Posted Date
- 2021-04-12
- Last Posted Date
- 2022-05-02
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 82
- Registration Number
- NCT04840888
- Locations
- 🇺🇸
LabCorp CRU, Inc., Daytona Beach, Florida, United States
🇺🇸Covance Dallas, Dallas, Texas, United States
The Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SH-1028
- Conditions
- Interventions
- First Posted Date
- 2021-03-22
- Last Posted Date
- 2021-03-22
- Lead Sponsor
- Nanjing Sanhome Pharmaceutical, Co., Ltd.
- Target Recruit Count
- 40
- Registration Number
- NCT04808648
- Locations
- 🇨🇳
the First Affiliated Hospital with Bengbu Medical College, Bengbu, Anhui, China
Drug-Drug Interaction Study Between EDP-514, Itraconazole, Carbamazepine, and Quinidine in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2021-03-05
- Last Posted Date
- 2021-08-16
- Lead Sponsor
- Enanta Pharmaceuticals, Inc
- Target Recruit Count
- 72
- Registration Number
- NCT04783753
- Locations
- 🇺🇸
Pharmaceutical Research Association, Lenexa, Kansas, United States
Drug Development Updates
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