Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
Drug Drug Interaction Trial With Strong CYP3A4 Inhibitor (Itraconazole) in CYP2C19 Extensive Metabolizers and Poor Metabolizers
- First Posted Date
- 2014-09-25
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 25
- Registration Number
- NCT02248259
- Locations
- 🇰🇷
1289.23.8201 Boehringer Ingelheim Investigational Site, Seoul, Korea, Republic of
Study to Assess Drug-Drug Interaction Between Itraconazole or Gemfibrozil and JNJ-56021927
- First Posted Date
- 2014-09-03
- Last Posted Date
- 2016-10-20
- Lead Sponsor
- Aragon Pharmaceuticals, Inc.
- Target Recruit Count
- 45
- Registration Number
- NCT02230033
Study to Evaluate the Effect of a Known and Marketed Product, Itraconazole (Mycosis Treatment) on Lu AF11167 Entering the Body and Subsequently Elimination. The Study is a Drug-drug Interaction Study in Healthy Volunteers.
- First Posted Date
- 2014-07-24
- Last Posted Date
- 2015-09-21
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 20
- Registration Number
- NCT02199431
- Locations
- 🇬🇧
Covance, Leeds, United Kingdom
A Study to Assess the Interaction Between ASP1707 and Itraconazole in Healthy Female Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-06-26
- Last Posted Date
- 2014-07-03
- Lead Sponsor
- Astellas Pharma Europe B.V.
- Target Recruit Count
- 14
- Registration Number
- NCT02175407
- Locations
- 🇩🇪
PAREXEL International GmbH, Berlin, Germany
Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva)
- Conditions
- Interventions
- First Posted Date
- 2014-06-06
- Last Posted Date
- 2024-03-19
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 39
- Registration Number
- NCT02157883
- Locations
- 🇬🇧
Research Site, Manchester, United Kingdom
A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP3700 in Healthy Male Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-06-04
- Last Posted Date
- 2014-10-30
- Lead Sponsor
- Astellas Pharma Europe B.V.
- Target Recruit Count
- 44
- Registration Number
- NCT02155504
- Locations
- 🇬🇧
Parexel Early Phase Clinical Unit, Harrow, United Kingdom
Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2014-05-05
- Last Posted Date
- 2016-12-13
- Lead Sponsor
- GlaxoSmithKline
- Registration Number
- NCT02130661
Effects of Fluconazole and Itraconazole CYP3A-Mediated Inhibition on the Pharmacokinetics, Safety, and Tolerability of MLN4924 in Participants With Advanced Solid Tumors
- Conditions
- Interventions
- First Posted Date
- 2014-04-25
- Last Posted Date
- 2019-01-07
- Lead Sponsor
- Millennium Pharmaceuticals, Inc.
- Target Recruit Count
- 51
- Registration Number
- NCT02122770
- Locations
- 🇺🇸
Sarah Cannon Cancer Center, Nashville, Tennessee, United States
🇺🇸Winship Cancer Institute at Emory University, Atlanta, Georgia, United States
🇺🇸Siteman Cancer Center - South County, Saint Louis, Missouri, United States
Effect of Multiple Doses of Itraconazole on the Multiple Dose Pharmacokinetics of Lu AE58054 in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-04-24
- Last Posted Date
- 2014-06-19
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 20
- Registration Number
- NCT02122692
- Locations
- 🇫🇷
FR801, Rennes, France
Topical Itraconazole in the Treatment of Basal Cell Carcinoma
- First Posted Date
- 2014-04-23
- Last Posted Date
- 2020-12-16
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 5
- Registration Number
- NCT02120677
- Locations
- 🇺🇸
Johns Hopkins School of Medicine, Department of Dermatology, Baltimore, Maryland, United States
Drug Development Updates
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