Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
Evaluate the Effects of Itraconazole and Ciprofloxacin on Single-Dose PK of Pracinostat in Healthy Nonsmoking Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-04-21
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Helsinn Healthcare SA
- Target Recruit Count
- 32
- Registration Number
- NCT02118909
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal Women
- First Posted Date
- 2014-04-01
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 24
- Registration Number
- NCT02100553
- Locations
- 🇺🇸
SeaView Research, Inc. (Screening Office), Miami, Florida, United States
🇺🇸SeaView Research, Inc., Miami, Florida, United States
To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers
- Conditions
- Interventions
- First Posted Date
- 2014-03-21
- Last Posted Date
- 2015-06-30
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 26
- Registration Number
- NCT02093728
- Locations
- 🇺🇸
Research Site, Overland Park, Kansas, United States
A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of JNJ-42165279 in Healthy Male Participants
- First Posted Date
- 2014-02-19
- Last Posted Date
- 2014-04-23
- Lead Sponsor
- Janssen Pharmaceutica N.V., Belgium
- Target Recruit Count
- 16
- Registration Number
- NCT02065739
A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil
- Conditions
- Interventions
- First Posted Date
- 2014-02-05
- Last Posted Date
- 2015-11-03
- Lead Sponsor
- Eisai Inc.
- Target Recruit Count
- 195
- Registration Number
- NCT02055703
- Locations
- 🇺🇸
WCT Early Development, San Antonio, Texas, United States
Phase Ib/II Study Evaluating Orteronel (Without Prednisone) Combined With Itraconazole In Men With Castration-Resistant Prostate Cancer (CRPC)
- Conditions
- First Posted Date
- 2014-02-04
- Last Posted Date
- 2014-07-23
- Lead Sponsor
- Emmanuel Antonarakis, MD
- Registration Number
- NCT02054793
- Locations
- 🇺🇸
Karmanos Cancer Institute, Detroit, Michigan, United States
🇺🇸Johns Hopkins University, Baltimore, Maryland, United States
🇺🇸Sibley Memorial Hospital, Washington, District of Columbia, United States
Interaction of BI 691751 With Itraconazole
- First Posted Date
- 2014-01-24
- Last Posted Date
- 2015-12-16
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 20
- Registration Number
- NCT02044393
- Locations
- 🇩🇪
1334.10.1 Boehringer Ingelheim Investigational Site, Biberach, Germany
Single and Multiple Dose Study of Uprifosbuvir (MK-3682/IDX21437) in Healthy and Hepatitis C Virus (HCV)-Infected Participants (MK-3682-001)
- Conditions
- Interventions
- First Posted Date
- 2013-11-01
- Last Posted Date
- 2018-09-13
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 178
- Registration Number
- NCT01974687
A Study of the Effect of Multiple Doses of Itraconazole and Fluoxetine on the Pharmacokinetics of a Single Dose of RO5285119 in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2013-10-23
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 28
- Registration Number
- NCT01967979
A Study to Evaluate Effect of Itraconazole on the Pharmacokinetics of Cobimetinib in Healthy Participants
- First Posted Date
- 2013-08-28
- Last Posted Date
- 2016-08-04
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT01929876
Drug Development Updates
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