Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications
- Conditions
- Interventions
- First Posted Date
- 2023-08-22
- Last Posted Date
- 2023-08-22
- Lead Sponsor
- Amgen
- Target Recruit Count
- 32
- Registration Number
- NCT06004947
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
A Drug-Drug Interaction Study to Assess the Pharmacokinetics of DC-806 When Orally Administered Alone, When Coadministered With Itraconazole, and When Coadministered With Carbamazepine in Healthy Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2023-08-16
- Last Posted Date
- 2023-10-04
- Target Recruit Count
- 33
- Registration Number
- NCT05994807
- Locations
- 🇺🇸
ICON Phase I Clinic, Salt Lake City, Utah, United States
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1815368 in the Blood
- First Posted Date
- 2023-07-28
- Last Posted Date
- 2023-11-03
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 14
- Registration Number
- NCT05965583
- Locations
- 🇩🇪
Humanpharmakologisches Zentrum Biberach, Biberach, Germany
A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2023-07-28
- Last Posted Date
- 2024-04-02
- Lead Sponsor
- Cerevel Therapeutics, LLC
- Target Recruit Count
- 60
- Registration Number
- NCT05965219
- Locations
- 🇺🇸
Overland Park, Kansas, Overland Park, Kansas, United States
Drug-durg Interaction of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid
- Conditions
- Interventions
- First Posted Date
- 2023-07-20
- Last Posted Date
- 2024-01-29
- Lead Sponsor
- Guangdong Raynovent Biotech Co., Ltd
- Target Recruit Count
- 49
- Registration Number
- NCT05954624
- Locations
- 🇨🇳
The First Affiliated Hospital of Guangzhou University of Chinese medicine, Guangzhou, China
A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2023-07-06
- Last Posted Date
- 2023-10-30
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 47
- Registration Number
- NCT05932303
- Locations
- 🇨🇦
Local Institution - 0001, Québec, CA, Canada
Efficacy and Safety of Terbinafine and Itraconazole
- Conditions
- Interventions
- First Posted Date
- 2023-05-31
- Last Posted Date
- 2023-05-31
- Lead Sponsor
- Dhaka Medical College
- Target Recruit Count
- 150
- Registration Number
- NCT05881980
Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor
- First Posted Date
- 2023-05-17
- Last Posted Date
- 2023-05-17
- Lead Sponsor
- Combined Military Hospital Abbottabad
- Target Recruit Count
- 164
- Registration Number
- NCT05862714
- Locations
- 🇵🇰
CMH Abbottabad, Abbottābād, Khyber Pakhtunkhwa, Pakistan
A Study of the Effects of Itraconazole or Carbamazepine on LY3537982 in Healthy Participants
- First Posted Date
- 2023-05-16
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 30
- Registration Number
- NCT05860933
- Locations
- 🇺🇸
ICON Early Development Services, Salt Lake City, Utah, United States
A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Drug-Drug Interaction Potential of Single and Multiple Doses of ALG-097558
- First Posted Date
- 2023-05-03
- Last Posted Date
- 2024-01-31
- Lead Sponsor
- Aligos Therapeutics
- Target Recruit Count
- 144
- Registration Number
- NCT05840952
- Locations
- 🇬🇧
Hammersmith Medicines Research, London, United Kingdom
Drug Development Updates
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