Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
An Open-label Study in Healthy Participants to Evaluate AZD0780 as an Object or Precipitant of CYP3A4-mediated Drug-drug Interactions
- Conditions
- Dyslipidaemia
- Interventions
- Drug: Ethinyl estradiol/levonorgestrel
- First Posted Date
- 2024-11-04
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 59
- Registration Number
- NCT06671405
- Locations
- 🇺🇸
Research Site, Brooklyn, Maryland, United States
A PK Study of IkT-148009 in Older and Elderly Healthy Subjects
- Conditions
- Healthy
- Interventions
- Drug: 100mg IkT-148009 WetDrug: 100mg IkT-148009 DryDrug: 50mg IkT-148009 Wet
- First Posted Date
- 2024-10-16
- Last Posted Date
- 2024-10-16
- Lead Sponsor
- Inhibikase Therapeutics, Inc.
- Target Recruit Count
- 8
- Registration Number
- NCT06644326
- Locations
- 🇺🇸
Celerion, Lincoln, Nebraska, United States
A Clinical Trial to Evaluate the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of VC004 Capsules in Healthy Adult Subjects
- Conditions
- Locally Advanced or Metastatic Solid Tumor
- Interventions
- First Posted Date
- 2024-10-01
- Last Posted Date
- 2024-12-10
- Lead Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
- Target Recruit Count
- 56
- Registration Number
- NCT06619951
- Locations
- 🇨🇳
Zhongda Hospital,Affiliated to Southeast University, Nanjing, Jiangsu, China
A Drug-Drug Interaction (DDI) Study of ADC189 With Itraconazole in Healthy, Adult Subjects
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2025-01-20
- Lead Sponsor
- Jiaxing AnDiCon Biotech Co.,Ltd
- Target Recruit Count
- 16
- Registration Number
- NCT06589635
- Locations
- 🇨🇳
The First Affilicated Hospital of Bengbu Medical University, Bengbu, Anhui, China
A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003)
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2024-12-18
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 12
- Registration Number
- NCT06586606
- Locations
- 🇺🇸
QPS-MRA, LLC ( Site 0001), South Miami, Florida, United States
A Study to Evaluate the Effect of Itraconazole on the Concentration of GSK3923868 in the Blood in Healthy Participants
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Interventions
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2025-03-07
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 20
- Registration Number
- NCT06597500
- Locations
- 🇬🇧
GSK Investigational Site, Cambridge, United Kingdom
A Study to Assess Multiple Ascending Dose, Drug-Drug Interaction, and Asian Pharmacokinetic Study of ABBV-1088
- Conditions
- Healthy Volunteer
- Interventions
- First Posted Date
- 2024-08-30
- Last Posted Date
- 2025-05-20
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 66
- Registration Number
- NCT06579300
- Locations
- 🇺🇸
Acpru /Id# 270552, Grayslake, Illinois, United States
A Drug-Drug Interaction (DDI) Study of HDM1002 With Rifampicin and Itraconazole in Healthy Subjects
- Conditions
- Healthy Adult Subject
- Interventions
- First Posted Date
- 2024-08-20
- Last Posted Date
- 2024-08-20
- Target Recruit Count
- 40
- Registration Number
- NCT06562088
- Locations
- 🇨🇳
The second hospital of anhui medical university, Hefei, Anhui, China
A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers
- Conditions
- Not Determined
- Interventions
- First Posted Date
- 2024-08-07
- Last Posted Date
- 2024-11-27
- Lead Sponsor
- BeiGene
- Target Recruit Count
- 30
- Registration Number
- NCT06543043
- Locations
- 🇺🇸
Quotient Sciences, Miami, Florida, United States
A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults.
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2024-08-07
- Last Posted Date
- 2025-03-28
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 16
- Registration Number
- NCT06541678
- Locations
- 🇺🇸
Pfizer Clinical Research Unit - New Haven, New Haven, Connecticut, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.