Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
A Study to Assess Change in How Oral Icalcaprant With Itraconazole Moves Through the Body in Healthy Adult Participants
- First Posted Date
- 2024-12-09
- Last Posted Date
- 2025-01-28
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 12
- Registration Number
- NCT06722430
- Locations
- 🇺🇸
Acpru /Id# 271617, Grayslake, Illinois, United States
A Study of the Effect of Itraconazole and Phenytoin on MK-1084 in Healthy Adults (MK-1084-008)
- First Posted Date
- 2024-12-06
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 28
- Registration Number
- NCT06719557
- Locations
- 🇺🇸
Celerion (Site 0001), Lincoln, Nebraska, United States
Investigation of Drug-drug Interaction of Ritonavir and Itraconazole on the Pharmacokinetics of SHR-A1811 in Subjects With HER2-expressing Advanced Breast Cancer
- Conditions
- Advanced Breast Cancer
- Interventions
- First Posted Date
- 2024-12-02
- Last Posted Date
- 2025-03-28
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 32
- Registration Number
- NCT06710990
- Locations
- 🇨🇳
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
🇨🇳Hunan Cancer Hospital, Changsha, Hunan, China
A Study to Learn if the Study Medicine Called Itraconazole and if Food Changes How the Body Processes the Other Study Medicine Called PF 07258669 in Older Adults or Healthy Adults
- First Posted Date
- 2024-11-27
- Last Posted Date
- 2025-03-25
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 26
- Registration Number
- NCT06706869
- Locations
- 🇺🇸
Research Centers of America ( Hollywood ), Hollywood, Florida, United States
🇺🇸Research Centers of America, Hollywood, Florida, United States
Drug-Drug Interaction and Food Effect of Sudapyridine(WX-081) With Itraconazole and Rifampin in Healthy Chinese Adults
- Conditions
- Rifampicin-Resistant Pulmonary Tuberculosis Patients
- Interventions
- First Posted Date
- 2024-11-22
- Last Posted Date
- 2025-02-12
- Lead Sponsor
- Shanghai Jiatan Pharmatech Co., Ltd
- Target Recruit Count
- 16
- Registration Number
- NCT06701136
A Study to Assess the Safety, Tolerability, and Interactions of ABBV-CLS-616 Oral Tablets in Healthy Adult Participants
- Conditions
- Healthy Volunteer
- Interventions
- First Posted Date
- 2024-11-21
- Last Posted Date
- 2024-11-21
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 112
- Registration Number
- NCT06698926
- Locations
- 🇺🇸
Acpru /Id# 270532, Grayslake, Illinois, United States
A Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Divarasib in Healthy Participants
- First Posted Date
- 2024-11-15
- Last Posted Date
- 2025-04-15
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 18
- Registration Number
- NCT06690138
- Locations
- 🇺🇸
Dallas Clinical Research Unit, Dallas, Texas, United States
A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)
- First Posted Date
- 2024-11-14
- Last Posted Date
- 2024-11-14
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 15
- Registration Number
- NCT06688045
- Locations
- 🇺🇸
Labcorp Clinical Research Unit Inc. (Site 0001), Honolulu, Hawaii, United States
A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healthy Participants
- Conditions
- Healthy Volunteer
- Interventions
- First Posted Date
- 2024-11-07
- Last Posted Date
- 2025-05-11
- Lead Sponsor
- Immunome, Inc.
- Target Recruit Count
- 22
- Registration Number
- NCT06677996
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
A Multi-part Study of ALG-000184 to Evaluate Safety, Tolerability, Pharmacokinetics and Drug-drug Interaction Potential After Single and Multiple Doses in Healthy Volunteers
- Conditions
- Healthy Volunteer
- Interventions
- First Posted Date
- 2024-11-04
- Last Posted Date
- 2025-02-03
- Lead Sponsor
- Aligos Therapeutics
- Target Recruit Count
- 24
- Registration Number
- NCT06672900
- Locations
- 🇺🇸
PPD Austin Research Unit, Austin, Texas, United States
Drug Development Updates
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