Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
Drug Interaction Study
- Conditions
- Interventions
- First Posted Date
- 2024-01-08
- Last Posted Date
- 2024-08-28
- Lead Sponsor
- Emalex Biosciences Inc.
- Target Recruit Count
- 45
- Registration Number
- NCT06194864
- Locations
- 🇨🇦
Syneos Health Clinic Inc., Québec, Quebec, Canada
A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary Aspergillosis
- Conditions
- Interventions
- First Posted Date
- 2023-12-18
- Last Posted Date
- 2024-04-17
- Target Recruit Count
- 300
- Registration Number
- NCT06174922
- Locations
- 🇮🇳
Chest Clinic, Dept. of Pulmonary Medicine, Chandigarh, India
A Study to Evaluate Potential Drug Interactions Between ALXN2080 and Itraconazole, Fluconazole & Carbamazepine in Healthy Adults
- Conditions
- Interventions
- First Posted Date
- 2023-12-15
- Last Posted Date
- 2024-06-20
- Lead Sponsor
- Alexion Pharmaceuticals, Inc.
- Target Recruit Count
- 60
- Registration Number
- NCT06173596
- Locations
- 🇬🇧
Research Site, Ruddington, United Kingdom
A Study to Assess the Effects of Itraconazole, Food, and pH on the Drug Levels of BMS-986368 in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2023-12-14
- Last Posted Date
- 2024-07-01
- Lead Sponsor
- Celgene
- Target Recruit Count
- 32
- Registration Number
- NCT06170723
- Locations
- 🇺🇸
Local Institution - 0001, Tempe, Arizona, United States
A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2023-12-08
- Last Posted Date
- 2024-06-13
- Lead Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
- Target Recruit Count
- 66
- Registration Number
- NCT06162169
- Locations
- 🇨🇳
Beijing GoBroad Hospital, Beijing, Beijing, China
A Phase 1, First-in-human Study of VX-828
- Conditions
- Interventions
- First Posted Date
- 2023-12-04
- Last Posted Date
- 2024-11-15
- Lead Sponsor
- Vertex Pharmaceuticals Incorporated
- Target Recruit Count
- 159
- Registration Number
- NCT06154447
- Locations
- 🇺🇸
Altasciences Clinical Kansas, Overland Park, Kansas, United States
Effect of Administration of Itraconazole on the Pharmacokinetics of S-309309 in Healthy Participants
- First Posted Date
- 2023-10-30
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 14
- Registration Number
- NCT06106334
- Locations
- 🇺🇸
Fortrea Clinical Research Unit Inc., Dallas, Texas, United States
Drug-Drug Interaction (DDI) Study for TPN171H
- Conditions
- Interventions
- First Posted Date
- 2023-10-19
- Last Posted Date
- 2023-10-19
- Lead Sponsor
- Vigonvita Life Sciences
- Target Recruit Count
- 24
- Registration Number
- NCT06090123
- Locations
- 🇨🇳
Shanghai Xuhui Central Hospital, Shanghai, Shanghai, China
Drug-Drug Interaction Study of Itraconazole With GST-HG171/Ritonavir in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2023-10-17
- Last Posted Date
- 2023-10-17
- Lead Sponsor
- Fujian Akeylink Biotechnology Co., Ltd.
- Target Recruit Count
- 12
- Registration Number
- NCT06087055
- Locations
- 🇨🇳
The first hospital of Jilin University, Changchun, Jilin, China
A Study in Healthy Men to Test Whether Itraconazole Influences the Amount of BI 1584862 in the Blood
- First Posted Date
- 2023-09-18
- Last Posted Date
- 2023-11-28
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 14
- Registration Number
- NCT06041438
- Locations
- 🇩🇪
Humanpharmakologisches Zentrum Biberach, Biberach, Germany
Drug Development Updates
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