Ofloxacin

Generic Name: Ofloxacin

Brand Names: Ocuflox

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₀FN_₃O_₄

CAS Number: 82419-36-1

Unique Ingredient Identifier: A4P49JAZ9H

Background: A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Indication: For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.

Associated Conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Acute Otitis Media (AOM), Bacterial Infections, Cervicitis, Community Acquired Pneumonia (CAP), Complicated Urinary Tract Infection, Conjunctivitis, Epididymitis, Hansen's Disease, Nongonococcal urethritis, Otitis Externa, Prostatitis, Skin and Subcutaneous Tissue Bacterial Infections, Spontaneous Bacterial Peritonitis (SBP), Traveler's Diarrhea, Ulcerative keratitis, Acute Pelvic inflammatory disease, Acute, uncomplicated Gonorrhea, Chronic suppurative Otitis media, Uncomplicated Cystitis

Clinical Trials

Diagnostics of Chronic Endometritis in Infertility

Not Applicable

Completed

Conditions: Infertility Unexplained
Abnormal Uterine Bleeding
Intrauterine Disorder

Interventions: Drug: Ofloxacin + Metronidazole

First Posted Date: 2023-07-14

Last Posted Date: 2025-04-18

Lead Sponsor: Jagiellonian University

Target Recruit Count: 102

Registration Number: NCT05946655

Locations: 🇵🇱
Jagiellonian University Medical College, Department of Gynecology and Obstetrics, Krakow, Malopolska, Poland

Trial to Evaluate the Efficacy and Safety of IVIEW-1201 in Acute Bacterial Conjunctivitis

Phase 2

Completed

Conditions: Acute Bacterial Conjunctivitis

Interventions: Drug: IVIEW-1201
Drug: Ofloxacin Eye Drops

First Posted Date: 2023-04-18

Last Posted Date: 2023-10-18

Lead Sponsor: IVIEW Therapeutics Inc.

Target Recruit Count: 129

Registration Number: NCT05816070

Locations: 🇨🇳
Eye Hospital of Shandong First Medical University, Jinan, SHAN DONG, China

Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome

Phase 1

Recruiting

Conditions: Short Bowel Syndrome
Infection, Bacterial

Interventions: Drug: Levofloxacin
Drug: Sulfamethoxazole trimethoprim
Drug: Ofloxacin
Drug: Amoxicillin

First Posted Date: 2022-03-31

Last Posted Date: 2024-08-29

Lead Sponsor: Central Hospital, Nancy, France

Target Recruit Count: 10

Registration Number: NCT05302531

Locations: 🇫🇷
CHRU Nancy, Vandœuvre-lès-Nancy, Lorraine, France

Ofloxacin Concentration-toxicity Relationship in the Elderly

Not Applicable

Recruiting

Conditions: Therapeutic Drug Monitoring
Ofloxacin
Bone and Joint Infection
Adverse Drug Reactions

First Posted Date: 2020-08-03

Last Posted Date: 2023-03-22

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 110

Registration Number: NCT04496024

Locations: 🇫🇷
CHU Amiens, Amiens, France

Nasal Ointment on Epistaxis of Nasotracheal Intubation in Children

Not Applicable

Completed

Conditions: Intubation
Epistaxis

Interventions: Drug: tarivid ointment

First Posted Date: 2020-06-11

Last Posted Date: 2022-07-26

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 108

Registration Number: NCT04426409

Locations: 🇰🇷
Ajou University School of Medicine, Suwon, Gyeong-gi, Korea, Republic of

Alternative Antibiotic Regimen in Periodontitis Treatment

Phase 4

Completed

Conditions: Amoxicillin
Metronidazole
Periodontitis
Ofloxacin
Root Planing

Interventions: Drug: Amoxicillin
Drug: Ofloxacin
Drug: Metronidazole

First Posted Date: 2020-04-20

Last Posted Date: 2020-04-20

Lead Sponsor: Istanbul Medipol University Hospital

Target Recruit Count: 74

Registration Number: NCT04353362

Locations: 🇹🇷
Begum Alkan, Istanbul, Turkey

Pilocarpine After Combined Cataract/Trabectome Surgery

Phase 3

Withdrawn

Conditions: Open Angle Glaucoma
Ocular Hypertension

Interventions: Drug: Pilocarpine
Drug: Ofloxacin
Drug: Prednisolone

First Posted Date: 2019-07-02

Last Posted Date: 2022-04-07

Lead Sponsor: Montefiore Medical Center

Registration Number: NCT04005079

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Pilocarpine Use After Kahook Goniotomy

Phase 3

Suspended

Conditions: Glaucoma

Interventions: Drug: Pilocarpine
Drug: Prednisolone
Drug: Ofloxacin

First Posted Date: 2019-05-01

Last Posted Date: 2024-07-22

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 142

Registration Number: NCT03933631

Locations: 🇺🇸
Montefiore Wakefield Campus, Bronx, New York, United States
🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present

Phase 4

Recruiting

Conditions: Otitis Media

Interventions: Drug: Ofloxacin otic solution

First Posted Date: 2018-08-31

Last Posted Date: 2024-07-09

Lead Sponsor: Boston Children's Hospital

Target Recruit Count: 125

Registration Number: NCT03655665

Locations: 🇺🇸
Boston Children's Hospital at Waltham, Waltham, Massachusetts, United States

Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media

Not Applicable

Completed

Conditions: Acute Otitis Media

Interventions: Device: Tympanostomy tube placement
Drug: Amoxicillin-Clavulanate and/or Ceftriaxone
Drug: Ofloxacin Otic

First Posted Date: 2015-10-05

Last Posted Date: 2022-07-15

Lead Sponsor: Alejandro Hoberman

Target Recruit Count: 250

Registration Number: NCT02567825

Locations: 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States
🇺🇸
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States

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