Ofloxacin

Generic Name: Ofloxacin

Brand Names: Ocuflox

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₀FN_₃O_₄

CAS Number: 82419-36-1

Unique Ingredient Identifier: A4P49JAZ9H

Background: A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Indication: For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.

Associated Conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Acute Otitis Media (AOM), Bacterial Infections, Cervicitis, Community Acquired Pneumonia (CAP), Complicated Urinary Tract Infection, Conjunctivitis, Epididymitis, Hansen's Disease, Nongonococcal urethritis, Otitis Externa, Prostatitis, Skin and Subcutaneous Tissue Bacterial Infections, Spontaneous Bacterial Peritonitis (SBP), Traveler's Diarrhea, Ulcerative keratitis, Acute Pelvic inflammatory disease, Acute, uncomplicated Gonorrhea, Chronic suppurative Otitis media, Uncomplicated Cystitis

Clinical Trials

VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia

Not Applicable

Completed

Conditions: Myopia
Refractive Errors

Interventions: Procedure: Small incision lenticule extraction
Drug: Tobramycin and dexamethasone
Drug: Ofloxacin
Drug: Proxymetacaine 0.5%
Drug: Oxybuprocaine 0.4%

First Posted Date: 2015-08-19

Last Posted Date: 2024-04-23

Lead Sponsor: London Vision Clinic

Target Recruit Count: 114

Registration Number: NCT02528123

Locations: 🇬🇧
London Vision Clinic, London, United Kingdom

Antibiotic Treatment for 7 Days Versus 14 Days in Patients With Acute Male Urinary Tract Infection

Phase 3

Completed

Conditions: Acute Male Urinary Tract Infection

Interventions: Drug: Ceftriaxone
Drug: Ofloxacine
Drug: Placebo of ofloxacine

First Posted Date: 2015-04-23

Last Posted Date: 2024-05-01

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 274

Registration Number: NCT02424461

Locations: 🇫🇷
Saint Louis hospital, Paris, France

Descemet Endothelial Thickness Comparison Trial

Phase 4

Conditions: Keratoplasty
Grafting, Corneal
Transplantation, Cornea
Keratoplasty, Lamellar
Transplantation, Corneal

Interventions: Procedure: DSAEK
Procedure: DMEK
Device: Endoserter
Drug: Prednisolone
Drug: Ofloxacin
Drug: Tropicamide
Device: Jones Tube
Drug: Phenylephrine

First Posted Date: 2015-02-26

Last Posted Date: 2020-11-25

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 38

Registration Number: NCT02373137

Locations: 🇺🇸
Byers Eye Institute, Stanford University, Palo Alto, California, United States
🇺🇸
F. I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States
🇺🇸
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States

Moxifloxacin Versus Ofloxacin Plus Metronidazole in Uncomplicated Pelvic Inflammatory Disease: Multicenter Randomized Controlled Trials

Phase 4

Completed

Conditions: Pelvic Inflammatory Disease

Interventions: Drug: Moxifloxacin
Drug: Ofloxacin
Drug: Metronidazole

First Posted Date: 2013-02-26

Last Posted Date: 2013-08-28

Lead Sponsor: Istanbul Bakirkoy Maternity and Children Diseases Hospital

Target Recruit Count: 1303

Registration Number: NCT01799356

Locations: 🇹🇷
T.C.S.B Mardin Women and Children Hospital, Mardin, Turkey
🇹🇷
T.C.S.B. İstanbul Training Research Hospital, Samatya, Fatih, Turkey
🇹🇷
T.C.S.B. Kanuni Sultan Suleyman Training Hospital, İstanbul, Kucukcekmece, Turkey

and more 1 locations