Doxycycline

Generic Name: Doxycycline

Brand Names: Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 564-25-0

Unique Ingredient Identifier: 334895S862

Background: Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is...

Indication: Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions: Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection

Associated Therapies: -

Clinical Trials

Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting Conditions

Phase 1

Completed

Conditions: To Determine Bioequivalence Under Fasting Conditions

Interventions: Drug: Doxycycline Monohydrate
Drug: Monodox

First Posted Date: 2008-04-04

Last Posted Date: 2008-04-04

Lead Sponsor: Par Pharmaceutical, Inc.

Target Recruit Count: 24

Registration Number: NCT00653380

Locations: 🇨🇦
Anapharm, Inc., Sainte-Foy, Quebec, Canada

Bioequivalence Study Doxycycline Tablets and Monodox Capsules Under Fasting Conditions

Phase 1

Completed

Conditions: To Determine Bioequivalence Under Fasting Conditions

Interventions: Drug: Doxycycline Monohydrate
Drug: Monodox

First Posted Date: 2008-04-04

Last Posted Date: 2008-04-04

Lead Sponsor: Par Pharmaceutical, Inc.

Target Recruit Count: 36

Registration Number: NCT00652795

Locations: 🇨🇦
Anapharm, Sainte-Foy, Quebec, Canada

Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting and Fed Conditions

Phase 1

Completed

Conditions: To Determine Bioequivalence Under Fed Conditions

Interventions: Drug: Doxycycline Monohydrate
Drug: Monodox

First Posted Date: 2008-04-04

Last Posted Date: 2017-09-26

Lead Sponsor: Par Pharmaceutical, Inc.

Target Recruit Count: 24

Registration Number: NCT00652704

Locations: 🇨🇦
Anapharm, Inc., Sainte-Foy, Quebec, Canada

Doxycycline for Lateral Epicondylalgia - RCT

Not Applicable

Conditions: Lateral Epicondylalgia (Tennis Elbow)

Interventions: Drug: Placebo
Drug: Doxycycline

First Posted Date: 2008-03-07

Last Posted Date: 2008-03-07

Lead Sponsor: Kaunas University of Medicine

Target Recruit Count: 34

Registration Number: NCT00631501

Locations: 🇱🇹
Dept of Orthopaedics, Kaunas Medical University, Kaunas, Lithuania

Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

Not Applicable

Completed

Conditions: Scrub Typhus

Interventions: Drug: doxycycline
Drug: rifampin

First Posted Date: 2007-12-06

Last Posted Date: 2019-02-08

Lead Sponsor: Dong-Min Kim

Target Recruit Count: 476

Registration Number: NCT00568711

Locations: 🇰🇷
Chosun University Hospital, Gwangju, Jeonnam, Korea, Republic of

The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm

Phase 2

Completed

Conditions: Aortic Aneurysm, Abdominal

Interventions: Drug: doxycycline

First Posted Date: 2007-10-03

Last Posted Date: 2007-10-03

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 60

Registration Number: NCT00538967

Locations: 🇳🇱
Leiden University Medical Center, Leiden, Netherlands

Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens

Phase 4

Completed

Conditions: Rosacea

Interventions: Drug: doxycycline

First Posted Date: 2007-07-03

Last Posted Date: 2008-12-16

Lead Sponsor: CollaGenex Pharmaceuticals

Target Recruit Count: 91

Registration Number: NCT00495313

Locations: 🇺🇸
Douglas Forsha, West Jordan, Utah, United States
🇺🇸
Angela Moore, Arlington, Texas, United States
🇺🇸
Bernard Goffe, Seattle, Washington, United States

and more 4 locations