Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
National University Hospital, Singapore, Singapore
University of Rochester, Rochester, New York, United States
Maine Children's Cancer Program, Scarborough, Maine, United States
St. Jude Affiliate Baton Rouge Clinic (Our Lady of the Lakes Regional Medical Center), Baton Rouge, Louisiana, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of
Gangnam Severance Hospital, Seoul, Korea, Republic of
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
University Medical Center Utrecht, Utrecht, Netherlands
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Local Institution - 167, Redwood City, California, United States
Local Institution - 161, Seattle, Washington, United States
Local Institution - 165, Houston, Texas, United States
Northwestern University, Chicago, Illinois, United States
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