TAS-102

Generic Name
TAS-102
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
-
CAS Number
733030-01-8
Unique Ingredient Identifier
-
Background

TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase inhibitor (TPI) tipiracil and the cytotoxin trifluridine. Trifluridine inhibits tumor growth by being incorporated into DNA during DNA synthesis. Tipiracil prevents trif...

Indication

用于治疗曾经接受氟嘧啶,奥沙利铂和伊立替康为基础的化疗,抗VEGF生物治疗和抗EGFR治疗(如果是RAS野生型)无效的转移性结直肠癌患者。

Associated Conditions
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Associated Therapies
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TAS-102 and Irinotecan in 2L+ Gastric and Gastroesophageal Adenocarcinoma

First Posted Date
2019-08-30
Last Posted Date
2024-02-02
Lead Sponsor
University of California, Irvine
Target Recruit Count
20
Registration Number
NCT04074343
Locations
🇺🇸

Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California, United States

🇺🇸

UC Davis Comprehensive Cancer Center, Sacramento, California, United States

Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer

First Posted Date
2019-06-11
Last Posted Date
2024-08-22
Lead Sponsor
Academic and Community Cancer Research United
Target Recruit Count
102
Registration Number
NCT03981614
Locations
🇺🇸

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States

🇺🇸

M D Anderson Cancer Center, Houston, Texas, United States

🇺🇸

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

and more 4 locations

Bioequivalence Study of Trifluridine and Tipiracil Tablets in Colorectal Cancer Patients

First Posted Date
2019-06-05
Last Posted Date
2022-04-19
Lead Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Target Recruit Count
64
Registration Number
NCT03974594
Locations
🇨🇳

Tangdu Hospital,Fourth Military Medical University, Xi'an, Shanxi, China

Sym004 Versus TAS-102 in Patients With mCRC

First Posted Date
2018-10-23
Last Posted Date
2019-02-04
Lead Sponsor
Symphogen A/S
Registration Number
NCT03717038

TAS102 in Combination With NAL-IRI in Advanced GI Cancers

First Posted Date
2017-12-11
Last Posted Date
2024-01-17
Lead Sponsor
Emory University
Target Recruit Count
64
Registration Number
NCT03368963
Locations
🇺🇸

Emory University Hospital Midtown, Atlanta, Georgia, United States

🇺🇸

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States

🇺🇸

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

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