Linezolid
- Generic Name
- Linezolid
- Brand Names
- Zyvox, Zyvoxam
- Drug Type
- Small Molecule
- Chemical Formula
- C16H20FN3O4
- CAS Number
- 165800-03-3
- Unique Ingredient Identifier
- ISQ9I6J12J
- Background
Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - ...
- Indication
Linezolid is indicated in adults and children for the treatment of infections caused by susceptible Gram-positive bacteria, including nosocomial pneumonia, community-acquired pneumonia, skin and skin structure infections, and vancomycin-resistant Enterococcus faecium infections. Examples of susceptible bacteria include Staphylococcus aureus, Streptococcus pn...
- Associated Conditions
- Community Acquired Pneumonia (CAP) caused by Staphylococcus Aureus Infections, Community acquired pneumonia caused by Susceptible strains of Streptococcus pneumoniae, Complicated Skin and Skin Structure Infection caused by Staphylococcus Aureus Infections, Complicated Skin and Skin Structure Infection caused by Streptococcus Agalactiae Infection, Complicated Skin and Skin Structure Infection caused by Streptococcus Pyogenes Infection, Nosocomial Pneumonia caused by Staphylococcus Aureus Infections, Nosocomial Pneumonia caused by Streptococcus Pneumoniae Infections, Uncomplicated Skin and Skin Structure Infections caused by Staphylococcus Aureus Infections, Uncomplicated Skin and Skin Structure Infections caused by Streptococcus Pyogenes Infection, Vancomycin-resistant Enterococcus faecium infection
- Associated Therapies
- -
Modified BPaL Regimen for Managing Pre-XDR TB and MDR (TI/NR) TB in India
- Conditions
- Interventions
- First Posted Date
- 2021-09-10
- Last Posted Date
- 2024-01-03
- Lead Sponsor
- Tuberculosis Research Centre, India
- Target Recruit Count
- 400
- Registration Number
- NCT05040126
- Locations
- 🇮🇳
S N Medical College, Agra, Uttarpradesh, India
PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN
- First Posted Date
- 2021-07-30
- Last Posted Date
- 2024-11-04
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 100
- Registration Number
- NCT04983901
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)-PLUS
- Conditions
- Interventions
- First Posted Date
- 2021-01-22
- Last Posted Date
- 2024-11-11
- Lead Sponsor
- Huashan Hospital
- Target Recruit Count
- 89
- Registration Number
- NCT04717908
- Locations
- 🇨🇳
The Third People's Hospital of Shenzhen City, Shenzhen, Guangzhou, China
🇨🇳The Central Hospital of Wenzhou City, Wenzhou, Zhejiang, China
🇨🇳Hwa Mei Hosptal,University of Chinese Academy of Sciences(Ningbo No.2 Hospital), Ningbo, Zhejiang, China
Finding the Optimal Regimen for Mycobacterium Abscessus Treatment
- Conditions
- Interventions
- First Posted Date
- 2020-03-17
- Last Posted Date
- 2024-12-11
- Lead Sponsor
- The University of Queensland
- Target Recruit Count
- 300
- Registration Number
- NCT04310930
- Locations
- 🇦🇺
St George Hospital, Kogarah, New South Wales, Australia
🇦🇺Austin Hospital, Heidelberg, Victoria, Australia
🇦🇺Royal Melbourne Hospital, Parkville, Victoria, Australia
Economic Evaluation of New MDR TB Regimens
- First Posted Date
- 2019-12-20
- Last Posted Date
- 2024-04-22
- Lead Sponsor
- Medecins Sans Frontieres, Netherlands
- Target Recruit Count
- 73
- Registration Number
- NCT04207112
- Locations
- 🇿🇦
THINK Clinical Trial Unit, Hillcrest, Durban, KwaZulu-Natal, South Africa
🇿🇦King DinuZulu Hospital, Durban, KwaZulu-Natal, South Africa
🇧🇾Republican Scientific and Practical Centre for Pulmonology and Tuberculosis hospital, Minsk, Belarus
Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)
- First Posted Date
- 2019-10-18
- Last Posted Date
- 2021-07-21
- Target Recruit Count
- 104
- Registration Number
- NCT04132115
- Locations
- 🇮🇹
Anesthesiology and Intensive Care Clinic - Department of Medicine - ASUIUD, Udine, Italy
🇮🇹Terapia Intensiva 1, Udine, Italy
PRACTECAL-PKPD Sub Study
- First Posted Date
- 2019-09-09
- Last Posted Date
- 2021-05-14
- Lead Sponsor
- Medecins Sans Frontieres, Netherlands
- Target Recruit Count
- 240
- Registration Number
- NCT04081077
- Locations
- 🇧🇾
Republican Scientific and Practical Centre for Pulmonology and Tuberculosis hospital, Minsk, Belarus
🇿🇦King DinuZulu Hospital, Durban, KwaZulu-Natal, South Africa
🇿🇦THINK Clinical Trial Unit, Hillcrest, Durban, KwaZulu-Natal, South Africa
Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections
- Conditions
- Interventions
- First Posted Date
- 2019-08-01
- Last Posted Date
- 2022-02-02
- Lead Sponsor
- Menarini Group
- Target Recruit Count
- 268
- Registration Number
- NCT04042077
- Locations
- 🇮🇹
Hospital Agostino Gemelli, Roma, Italy
Patient-reported Experiences and Quality of Life Outcomes in the TB-PRACTECAL Clinical Trial
- First Posted Date
- 2019-05-08
- Last Posted Date
- 2024-05-29
- Lead Sponsor
- Medecins Sans Frontieres, Netherlands
- Target Recruit Count
- 137
- Registration Number
- NCT03942354
- Locations
- 🇧🇾
Republican Scientific and Practical Centre for Pulmonology and Tuberculosis hospital, Minsk, Belarus
🇺🇿Sh Alimov Republican Specialised Scientific-Practical Medical Centre for Phthysiology and Pulmonology Hospital, Tashkent, Uzbekistan
🇿🇦Helen Jospeh Hospital, Johannesburg, South Africa
Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM
- First Posted Date
- 2019-04-25
- Last Posted Date
- 2021-09-28
- Lead Sponsor
- University of Cape Town
- Target Recruit Count
- 52
- Registration Number
- NCT03927313
- Locations
- 🇿🇦
Mitchells Plain Hospital, Cape Town, Western Cape, South Africa
🇿🇦Livingstone Hospital, Port Elizabeth, Eastern Cape, South Africa
🇿🇦New Somerset Hospital, Cape Town, Western Cape, South Africa
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.