Thiamine

Generic Name
Thiamine
Brand Names
Alertonic, Concept Ob, Fortaplex, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Pregvit, Tandem Plus, Vitafol-one
Drug Type
Small Molecule
Chemical Formula
C12H17N4OS
CAS Number
70-16-6
Unique Ingredient Identifier
4ABT0J945J
Background

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose meta...

Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Associated Conditions
Anemia, B12 Deficiency Anemia, Beriberi, Cardiovascular Heart Disease caused by Thiamine Deficiency, Folic Acid Deficiency Anemia, Infantile Beriberi, Infection, Iron Deficiency (ID), Neuritis caused by Pregnancy, Secondary anemia, Thiamine Deficiency, Vitamin Deficiency, Wernicke's encephalopathy, Liver disorders
Associated Therapies
Nutritional supplementation, Vitamin supplementation, Dietary supplementation
Clinical Trials
Related News

Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.

Not Applicable
Conditions
Familial Adenomatous Polyposis (FAP)
Interventions
Drug: Vitamin B1
First Posted Date
2024-10-21
Last Posted Date
2024-10-21
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
10
Registration Number
NCT06649825
Locations
🇨🇳

Shanghai Zhongshan Hospital, Shanghai, Shanghai, China

Thiamine Intervention and Coronary Artery Bypass Grafting

First Posted Date
2024-03-25
Last Posted Date
2024-10-30
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
52
Registration Number
NCT06326996
Locations
🇺🇸

UCLA, Los Angeles, California, United States

The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease

First Posted Date
2024-03-07
Last Posted Date
2024-05-08
Lead Sponsor
Universitas Sumatera Utara
Target Recruit Count
88
Registration Number
NCT06298344
Locations
🇮🇩

RSUP H Adam Malik, Medan, North Sumatera, Indonesia

Supplemental Thiamine in Septic Shock: A Before-after Study

Completed
Conditions
Septic Shock
Interventions
Drug: Thiamin
First Posted Date
2023-05-03
Last Posted Date
2024-04-18
Lead Sponsor
Hospital Sao Domingos
Target Recruit Count
73
Registration Number
NCT05840718
Locations
🇧🇷

Hospital São Domingos, São Luís, Maranhão, Brazil

🇧🇷

Hospital Sao Domingos, Sao Luis, MA, Brazil

Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa

First Posted Date
2021-08-10
Last Posted Date
2021-09-08
Lead Sponsor
Liverpool School of Tropical Medicine
Target Recruit Count
60
Registration Number
NCT04999137
Locations
🇺🇬

Infectious Diseases Institute, Makerere University, Kampala, Uganda

🇺🇬

Kiruddu National Referral Hospital, Kampala, Uganda

PBC Induced Fatigue Treated With Thiamine

First Posted Date
2021-05-20
Last Posted Date
2021-05-20
Lead Sponsor
Henning Grønbæk
Target Recruit Count
36
Registration Number
NCT04893993
Locations
🇩🇰

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark, Aarhus N, Region Midtjylland, Denmark

Effect of Intravenous Vitamin C on SOFA Score Among Septic Patients

Not Applicable
Completed
Conditions
Sepsis
Interventions
Drug: vitamin C, vitamin B1
Drug: vitamin B1
First Posted Date
2019-10-24
Last Posted Date
2020-01-02
Lead Sponsor
Indonesia University
Target Recruit Count
33
Registration Number
NCT04137276
Locations
🇮🇩

Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, Indonesia

Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs

Phase 3
Conditions
Heart Diseases
Interventions
Drug: Thiamine Mononitrate
First Posted Date
2019-06-18
Last Posted Date
2019-06-20
Lead Sponsor
Mahidol University
Target Recruit Count
60
Registration Number
NCT03989700
Locations
🇹🇭

Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients

First Posted Date
2018-08-28
Last Posted Date
2018-08-31
Lead Sponsor
Universiti Kebangsaan Malaysia Medical Centre
Target Recruit Count
72
Registration Number
NCT03649009
Locations
🇲🇾

Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia

Thiamin Against Robust IBD Fatigue

Phase 4
Completed
Conditions
Fatigue
Interventions
Drug: Thiamine
Other: Placebo
First Posted Date
2018-08-16
Last Posted Date
2020-10-29
Lead Sponsor
University of Aarhus
Target Recruit Count
40
Registration Number
NCT03634735
Locations
🇩🇰

Aarhus University Hospital, Aarhus, Central Region, Denmark

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