Thiamine
- Generic Name
- Thiamine
- Brand Names
- Alertonic, Concept Ob, Fortaplex, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Pregvit, Tandem Plus, Vitafol-one
- Drug Type
- Small Molecule
- Chemical Formula
- C12H17N4OS
- CAS Number
- 70-16-6
- Unique Ingredient Identifier
- 4ABT0J945J
- Background
Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.
- Indication
For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.
- Associated Conditions
- Anemia, B12 Deficiency Anemia, Beriberi, Cardiovascular Heart Disease caused by Thiamine Deficiency, Folic Acid Deficiency Anemia, Infantile Beriberi, Infection, Iron Deficiency (ID), Neuritis caused by Pregnancy, Secondary anemia, Thiamine Deficiency, Vitamin Deficiency, Wernicke's encephalopathy, Liver disorders
- Associated Therapies
- Nutritional supplementation, Vitamin supplementation, Dietary supplementation
Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
- Conditions
- Lactic AcidosisThiamin DeficiencyCardiac ArrestShock
- Interventions
- Drug: ThiamineOther: placebo
- First Posted Date
- 2016-11-28
- Last Posted Date
- 2022-08-09
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 36
- Registration Number
- NCT02974257
- Locations
- ๐บ๐ธ
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Optimum Thiamine Intervention (OpTIn) Trial
- First Posted Date
- 2016-06-02
- Last Posted Date
- 2019-08-16
- Lead Sponsor
- Menzies School of Health Research
- Target Recruit Count
- 334
- Registration Number
- NCT02788552
- Locations
- ๐ฆ๐บ
Alice Springs Hospital, Alice Springs, Northern Territory, Australia
Thiamine Supplement in Patients With Severe Hyperthyroidism
- First Posted Date
- 2016-05-10
- Last Posted Date
- 2016-10-04
- Lead Sponsor
- Ramathibodi Hospital
- Target Recruit Count
- 12
- Registration Number
- NCT02767245
- Locations
- ๐น๐ญ
Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Thiamine as an Adjunctive Therapy in Cardiac Surgery
- Conditions
- Coronary Artery BypassCardiac Surgical Procedures
- Interventions
- Drug: Normal saline solutionDrug: Thiamine
- First Posted Date
- 2014-12-23
- Last Posted Date
- 2017-03-30
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 64
- Registration Number
- NCT02322892
- Locations
- ๐บ๐ธ
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement
- Conditions
- Sciatica Due to Intervertebral Disc Disorder
- Interventions
- First Posted Date
- 2014-03-14
- Last Posted Date
- 2014-03-14
- Lead Sponsor
- Chengdu University of Traditional Chinese Medicine
- Target Recruit Count
- 324
- Registration Number
- NCT02087462
- Locations
- ๐จ๐ณ
Chengdu university of Traditonal Chinese Medcine, Chengdu, Sichuan, China
The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
- First Posted Date
- 2013-11-15
- Last Posted Date
- 2017-10-02
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 66
- Registration Number
- NCT01985685
- Locations
- ๐บ๐ธ
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness
- First Posted Date
- 2011-10-31
- Last Posted Date
- 2018-01-16
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT01462279
- Locations
- ๐บ๐ธ
Beth Israel Deaconess Medical Center (BIDMC), Boston, Massachusetts, United States
Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy
- First Posted Date
- 2010-05-04
- Last Posted Date
- 2010-12-23
- Lead Sponsor
- Mashhad University of Medical Sciences
- Target Recruit Count
- 50
- Registration Number
- NCT01115504
- Locations
- ๐ฎ๐ท
Faculty of medicine, Azad university, Shahrood, Semnan, Iran, Islamic Republic of
Thiamine as a Metabolic Resuscitator in Septic Shock
- First Posted Date
- 2010-02-18
- Last Posted Date
- 2017-05-15
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 88
- Registration Number
- NCT01070810
- Locations
- ๐บ๐ธ
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
- First Posted Date
- 2008-10-09
- Last Posted Date
- 2011-06-27
- Lead Sponsor
- Luzerner Kantonsspital
- Target Recruit Count
- 12
- Registration Number
- NCT00770107
- Locations
- ๐จ๐ญ
Kantonsspital Luzern, Luzern, Switzerland
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.