Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Indicated for:
1) Prophylaxis and treatment of venous thromboembolism and related pulmonary embolism.
2) Prophylaxis and treatment of thromboembolism associated with atrial fibrillation.
3) Prophylaxis and treatment of thromboembolism associated with cardiac valve replacement.
4) Use as adjunct therapy to reduce mortality, recurrent myocardial infarction, and thromboembolic events post myocardial infarction.
Off-label uses include:
1) Secondary prevention of stroke and transient ischemic attacks in patients with rheumatic mitral valve disease but without atrial fibrillation.
State Research Institute of CIrculation Pathology Novosibirsk, Russian Federation, Novosibirsk, Russian Federation
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Union Hospital Tongji Medical College Huazhong University of Science and technology, Wuhan, Hubei, China
Cancer Therapy & Research Center UT Health Science Center SC-4, San Antonio, Texas, United States
Henry Ford Hospital SC, Detroit, Michigan, United States
Karmanos Cancer Institute Oncology Department, Detroit, Michigan, United States
Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
University of Alberta, Edmonton, Alberta, Canada
Los Angeles Biomedical Research Institute, Torrance, California, United States
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