Piperacillin-Tazobactam
- Generic Name
- Piperacillin-Tazobactam
- Indication
适用于产β内酰胺酶而对哌拉西林耐药、但对本品敏感的细菌（如大肠埃希菌、克雷伯菌属、柠檬酸杆菌属、肠杆菌属、沙雷菌属、变形杆菌属、摩根菌属、雷极普罗维登菌、铜绿假单胞菌、流感嗜血杆菌、不动杆菌属、葡萄球菌属和拟杆菌属等）所致的下列中、重度感染：
1.肺炎、肺脓肿、脓胸、支气管扩张合并感染和慢性阻塞性肺病继发性感染等下呼吸道感染；
2.创伤或外科伤口继发皮肤软组织感染、蜂窝织炎、皮肤脓肿、糖尿病足感染；
3.胆囊炎、胆管炎、肝脓肿和腹膜炎等腹腔感染；
4.盆腔炎、子宫内膜炎、子宫周围炎、附件炎、盆腔脓肿等生殖系统感染；
5.单纯或复杂性尿路感染。本品用于铜绿假单胞菌严重感染时，应联合氨基糖苷类等其他抗铜绿假单胞菌的药物。
Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response
- Conditions
- Bloodstream Infections
- Interventions
- First Posted Date
- 2015-05-07
- Last Posted Date
- 2023-05-10
- Lead Sponsor
- The University of Queensland
- Target Recruit Count
- 100
- Registration Number
- NCT02437045
- Locations
- 🇦🇺
John Hunter Hospital, New Lambton, New South Wales, Australia
🇸🇬National University Hospital Singapore, Singapore, Singapore
🇦🇺Wollongong Hospital, Wollongong, New South Wales, Australia
RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp.
- Conditions
- Bloodstream Infections
- Interventions
- First Posted Date
- 2014-06-26
- Last Posted Date
- 2017-11-27
- Lead Sponsor
- The University of Queensland
- Target Recruit Count
- 391
- Registration Number
- NCT02176122
- Locations
- 🇮🇹
Catholic University Rome, Rome, Italy
🇹🇷İstanbul Medipol Üniversitesi Medipol Mega Hastaneler Kompleksi (Medipol Mega Hospitals Complex), Istanbul, Turkey
🇦🇺Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP
- Conditions
- Acute PyelonephritisUrinary Tract Infection Complicated
- Interventions
- First Posted Date
- 2014-06-18
- Last Posted Date
- 2018-06-11
- Lead Sponsor
- Melinta Therapeutics, Inc.
- Target Recruit Count
- 550
- Registration Number
- NCT02166476
Antibiotic Safety (SCAMP)
- Conditions
- Complicated Intra Abdominal Infections
- Interventions
- First Posted Date
- 2013-11-26
- Last Posted Date
- 2019-05-30
- Lead Sponsor
- Michael Cohen-Wolkowiez
- Target Recruit Count
- 260
- Registration Number
- NCT01994993
- Locations
- 🇺🇸
Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts, United States
🇺🇸Texas Children's Hospital, Houston, Texas, United States
🇺🇸Wesley Medical Center, Wichita, Kansas, United States
Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia
- Conditions
- FebrileNeutropeniaHematopoietic Stem Cell Transplantation
- Interventions
- First Posted Date
- 2012-10-26
- Last Posted Date
- 2014-04-17
- Lead Sponsor
- Chinese PLA General Hospital
- Target Recruit Count
- 123
- Registration Number
- NCT01714570
- Locations
- 🇨🇳
Chinese PLA general hospital, Beijing, Beijing, China
Prophylactic Piperacillin/Tazobactam in Hematopoietic Stem Cell Transplantation
- Conditions
- NeutropeniaHematopoietic Stem Cell Transplantation
- Interventions
- First Posted Date
- 2012-10-26
- Last Posted Date
- 2012-10-26
- Lead Sponsor
- Chinese PLA General Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT01714557
- Locations
- 🇨🇳
Chinese PLA general hospital, Beijing, Beijing, China
Continuous Infusion Piperacillin-tazobactam for the Treatment of Cystic Fibrosis
- Conditions
- Cystic Fibrosis
- Interventions
- First Posted Date
- 2012-09-26
- Last Posted Date
- 2022-02-01
- Lead Sponsor
- West Virginia University
- Target Recruit Count
- 6
- Registration Number
- NCT01694069
- Locations
- 🇺🇸
West Virginia University Healthcare, Morgantown, West Virginia, United States
Piperacillin-Tazobactam Continuous Versus Intermittent Infusion for Pseudomonas Aeruginosa
- Conditions
- Pseudomonas Aeruginosa Infection
- Interventions
- First Posted Date
- 2012-04-13
- Last Posted Date
- 2014-09-22
- Target Recruit Count
- 76
- Registration Number
- NCT01577368
- Locations
- 🇪🇸
Hospital Universitario Virgen del Rocío, Seville, Spain
Role of Antibiotics in Preventing Infection in Babies Born Through Meconium Stained Liquor
- Conditions
- Neonatal Sepsis
- Interventions
- First Posted Date
- 2011-02-04
- Last Posted Date
- 2015-09-29
- Lead Sponsor
- Lady Hardinge Medical College
- Target Recruit Count
- 250
- Registration Number
- NCT01290003
- Locations
- 🇮🇳
Kalawati Saran children's Hospital, Lady Hardinge Medical College, New Delhi, Delhi, India
Pharmacokinetics and Safety of Piperacillin-tazobactam in Neonates
- First Posted Date
- 2009-04-01
- Last Posted Date
- 2018-10-03
- Lead Sponsor
- Phillip Brian Smith
- Target Recruit Count
- 32
- Registration Number
- NCT00873327
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
🇺🇸Indiana University School of Medicine, Indianapolis, Indiana, United States
🇺🇸Wesley Medical Center, Wichita, Kansas, United States
Drug Development Updates
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