Acyclovir
- Generic Name
- Acyclovir
- Brand Names
- Sitavig, Xerese, Zovirax
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11N5O3
- CAS Number
- 59277-89-3
- Unique Ingredient Identifier
- X4HES1O11F
- Background
Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.
Acyclovir was granted FDA approval on 29 March 1982.
- Indication
An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients. An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older. An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis. An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.
- Associated Conditions
- Bell's Palsy, Chickenpox, Cytomegalovirus (CMV) Infections, Herpes Simplex Infections, Herpes Zoster, Herpes simplex encephalitis, Herpes simplex of the oral-labial, Herpes simplex type I reactivation, Recurrent Genital Herpes (RGH), Recurrent Herpes Labialis, VZV re-activation, Acute Genital herpes, Acute Herpes labialis, Acute Herpetic keratitis, Severe Genital herpes
Herpetic Eye Disease Study (HEDS) I
- Conditions
- Keratitis, HerpeticOcular Herpes Simplex
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2009-09-17
- Lead Sponsor
- National Eye Institute (NEI)
- Registration Number
- NCT00000138
Herpetic Eye Disease Study (HEDS) II
- Conditions
- Herpes SimplexKeratitis, HerpeticOcular Herpes Simplex
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2010-03-24
- Lead Sponsor
- National Eye Institute (NEI)
- Registration Number
- NCT00000139
- Locations
- 🇺🇸
Wills Eye Hospital, Cornea Clinic, Philadelphia, Pennsylvania, United States
🇺🇸Department of Ophthalmology, The Mount Sinai Medical Center, New York, New York, United States
🇺🇸Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States
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