Metoprolol

Generic Name: Metoprolol

Brand Names: Kapspargo, Lopressor, Lopressor Hct, Toprol

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₂₅NO_₃

CAS Number: 51384-51-1

Unique Ingredient Identifier: GEB06NHM23

Background: Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release. The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date, it is one of the preferre...

Indication: Metoprolol is indicated for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation, atrial flutter and hypertension.

Some off-label uses of metoprolol include supraventricular tachycardia and thyroid storm.
...

Associated Conditions: Angina Pectoris, Atrial Fibrillation, Hypertension, Migraine, Myocardial Infarction, Supraventricular Tachycardia (SVT), Thyroid Crisis, Chronic heart failure with reduced ejection fraction (NYHA Class II), Chronic heart failure with reduced ejection fraction (NYHA Class III)

Associated Therapies: -

Clinical Trials

Effect of BMS-914392 on Pharmacokinetics of Metoprolol

Phase 1

Completed

Conditions: Atrial Fibrillation

Interventions: Drug: metoprolol
Drug: BMS-914392

First Posted Date: 2010-09-30

Last Posted Date: 2011-02-02

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 18

Registration Number: NCT01211821

Locations: 🇺🇸
Pra International, Lenexa, Kansas, United States

Pharmacogenomic Evaluation of Antihypertensive Responses 2

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Metoprolol
Drug: Chlorthalidone

First Posted Date: 2010-09-16

Last Posted Date: 2018-04-06

Lead Sponsor: University of Florida

Target Recruit Count: 839

Registration Number: NCT01203852

Locations: 🇺🇸
University of Florida, Gainesville, Florida, United States
🇺🇸
Emory University School of Medicine, Atlanta, Georgia, United States
🇺🇸
Mayo Clinic, Division of Hypertension, Rochester, Minnesota, United States

Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation

Phase 4

Completed

Conditions: Aortic Valve Insufficiency

Interventions: Drug: Placebo
Drug: Metoprolol

First Posted Date: 2010-07-07

Last Posted Date: 2014-09-25

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 75

Registration Number: NCT01157572

Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Nebivolol
Drug: Metoprolol

First Posted Date: 2010-07-05

Last Posted Date: 2024-11-06

Lead Sponsor: University of Florida

Target Recruit Count: 32

Registration Number: NCT01157234

Locations: 🇺🇸
University of Florida, Gainesville, Florida, United States

Impact of Nebivolol on Central Aortic Pressure

Not Applicable

Withdrawn

Conditions: Central Aortic Pressure

Interventions: Drug: Nebivolol
Drug: Metoprolol

First Posted Date: 2010-01-20

Last Posted Date: 2011-08-01

Lead Sponsor: Creighton University

Registration Number: NCT01051947

Locations: 🇺🇸
The Cardiac Center at Creighton University, Omaha, Nebraska, United States

The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals

Phase 4

Withdrawn

Conditions: Blood Pressure

Interventions: Drug: placebo
Drug: ivabradine
Drug: metoprolol

First Posted Date: 2009-12-09

Last Posted Date: 2011-11-09

Lead Sponsor: Bayside Health

Target Recruit Count: 42

Registration Number: NCT01029223

Nebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of Life

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: Metoprolol
Drug: Nebivolol

First Posted Date: 2009-10-21

Last Posted Date: 2018-10-19

Lead Sponsor: Weill Medical College of Cornell University

Target Recruit Count: 37

Registration Number: NCT00999102

Locations: 🇺🇸
Weill Cornell Medical College, New York, New York, United States

A Weight Loss Study in Overweight Men and Women

Phase 2

Terminated

Conditions: Obesity

Interventions: Drug: LY377604
Drug: Placebo sibutramine
Drug: Placebo Metoprolol
Drug: Sibutramine
Drug: Metoprolol
Drug: Placebo LY377604

First Posted Date: 2009-10-12

Last Posted Date: 2011-06-03

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 343

Registration Number: NCT00993421

Locations: 🇺🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Richmond, Virginia, United States

Nebivolol Versus Metoprolol: Sodium Sensitivity

Phase 4

Completed

Conditions: Hypertension

Interventions: Drug: nebivolol
Drug: Metoprolol

First Posted Date: 2009-10-08

Last Posted Date: 2017-06-08

Lead Sponsor: University of Miami

Target Recruit Count: 24

Registration Number: NCT00992056

Locations: 🇺🇸
Division of Clinical Pharmacology Clinical Pharmacology Research Unit (CPRU) 1500 NW 12th Ave 15-West., Miami, Florida, United States

Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate

Not Applicable

Terminated

Conditions: Hypertension

Interventions: Drug: Metoprolol
Drug: Nebivolol

First Posted Date: 2009-02-24

Last Posted Date: 2013-03-19

Lead Sponsor: University of Mississippi Medical Center

Target Recruit Count: 1

Registration Number: NCT00849810

Locations: 🇺🇸
University of Mississippi Medical Center, Jackson, Mississippi, United States

Drug Development Updates

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