DeepMed Research

Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Treatment of Refractory Status Epilepticus

Phase 3

Terminated

Conditions: Status Epilepticus

Interventions: Drug: thiopental/pentobarbital
Drug: propofol

First Posted Date: 2005-12-15

Last Posted Date: 2013-04-09

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 23

Registration Number: NCT00265616

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇨🇭
Inselspital, Bern, BE, Switzerland
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

and more 2 locations

Pain of Injection of Lipuro Propofol in Children Aged 1-7 Years

Not Applicable

Completed

Conditions: ASA 1-2 Requiring Intravenous Cannulation for General Anaesthesia

First Posted Date: 2005-10-05

Last Posted Date: 2007-03-28

Lead Sponsor: Institute of Child Health

Registration Number: NCT00232895

Locations: 🇬🇧
Great Ormond Street Hospital, London, United Kingdom

Propofol Injection for Daily Headache

Phase 2

Completed

Conditions: Chronic Headache
Analgesic Rebound Headache
Chronic Daily Headache
Headache, Intractable

First Posted Date: 2005-09-28

Last Posted Date: 2017-05-04

Lead Sponsor: University of Alberta

Target Recruit Count: 28

Registration Number: NCT00228267

Locations: 🇨🇦
Multidisciplinary Pain Centre, Univ. Alta Hospital, Edmonton, Alberta, Canada

Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy

Phase 3

Completed

Conditions: Hepatectomy

Interventions: Drug: Penthotal
Drug: Propofol
Drug: Desflurane

First Posted Date: 2005-09-22

Last Posted Date: 2012-06-26

Lead Sponsor: Rennes University Hospital

Target Recruit Count: 34

Registration Number: NCT00219856

Locations: 🇫🇷
Surgical Intensive Care Unit - Rennes University Hospital, Rennes, France

Comparison of AQUAVAN® Injection to DISOPRIVAN® Injectable Emulsion for Anesthesia During Coronary Artery Surgery

Phase 2

Completed

Conditions: Ischemic Coronary Artery Disease
Coronary Artery Bypass Surgery

Interventions: Drug: propofol
Drug: fospropofol

First Posted Date: 2005-09-21

Last Posted Date: 2010-06-11

Lead Sponsor: Eisai Inc.

Target Recruit Count: 16

Registration Number: NCT00209521

Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma

Not Applicable

Completed

Conditions: Leukemia
Lymphoma

First Posted Date: 2005-09-21

Last Posted Date: 2015-10-05

Lead Sponsor: University of Wisconsin, Madison

Target Recruit Count: 40

Registration Number: NCT00214370

Locations: 🇺🇸
University of Wisconsin, Madison, Wisconsin, United States

Study of Fentanyl-Propofol-EMLA of L.M.X4 Technique for Bone Marrow Aspiration

Phase 3

Terminated

Conditions: Pain
Bone Marrow Disease

Interventions: Drug: Fentanyl
Drug: EMLA
Drug: L.M.X4
Drug: Propofol

First Posted Date: 2005-09-16

Last Posted Date: 2017-04-04

Lead Sponsor: St. Jude Children's Research Hospital

Target Recruit Count: 168

Registration Number: NCT00187135

Locations: 🇺🇸
St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects

Phase 4

Completed

Conditions: Sedation

First Posted Date: 2005-09-12

Last Posted Date: 2008-10-16

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 224

Registration Number: NCT00158873

Locations: 🇳🇱
GSK Investigational Site, Zwolle, Netherlands

Effect of Affective Content on Drug Induced Amnesia of Episodic Memory

Phase 1

Completed

Conditions: Memory Losses
Amnesia-Memory Loss

Interventions: Drug: Propofol
Drug: Thiopental Sodium
Drug: Dexmedetomidine Hydrochloride
Drug: Midazolam Hydrochloride
Drug: placebo

First Posted Date: 2005-09-02

Last Posted Date: 2015-12-24

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 79

Registration Number: NCT00142493

Locations: 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy

Not Applicable

Completed

Conditions: Respiration Disorders

First Posted Date: 1999-10-19

Last Posted Date: 2015-03-25

Lead Sponsor: FDA Office of Orphan Products Development

Target Recruit Count: 120

Registration Number: NCT00004424

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