Propofol
- Generic Name
- Propofol
- Brand Names
- Diprivan
- Drug Type
- Small Molecule
- Chemical Formula
- C12H18O
- CAS Number
- 2078-54-8
- Unique Ingredient Identifier
- YI7VU623SF
- Background
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
- Indication
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
- Associated Conditions
- -
- Associated Therapies
- Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients
- Conditions
- Interventions
- First Posted Date
- 2022-08-08
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- Xiaobo Yang, MD
- Target Recruit Count
- 60
- Registration Number
- NCT05491278
- Locations
- 🇨🇳
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
- First Posted Date
- 2022-08-03
- Last Posted Date
- 2024-07-26
- Lead Sponsor
- Haisco-USA Pharmaceuticals, Inc.
- Target Recruit Count
- 466
- Registration Number
- NCT05486416
- Locations
- 🇵🇱
Uniwersytecki Szpital Kliniczny W Opolu, Opole, Poland
🇺🇸Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸The Ohio State University Wexner Medical Center, Columbus, Ohio, United States
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
- First Posted Date
- 2022-07-28
- Last Posted Date
- 2024-10-29
- Lead Sponsor
- Haisco-USA Pharmaceuticals, Inc.
- Target Recruit Count
- 400
- Registration Number
- NCT05478174
- Locations
- 🇺🇸
Phoenix Clinical Research, Tamarac, Florida, United States
🇺🇸Chesapeake Research Group, Llc, Pasadena, Maryland, United States
🇺🇸The Ohio State University Wexner Medical Center, Columbus, Ohio, United States
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
- First Posted Date
- 2022-07-21
- Last Posted Date
- 2022-10-26
- Lead Sponsor
- Zhejiang Cancer Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT05468671
- Locations
- 🇨🇳
Zhejiang Cancer Hospital, Hanzhou, China
The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients
- Conditions
- Interventions
- First Posted Date
- 2022-07-20
- Last Posted Date
- 2024-01-25
- Lead Sponsor
- Fang Jun
- Target Recruit Count
- 131
- Registration Number
- NCT05466279
- Locations
- 🇨🇳
Zhejiang Cancer Hospital, Hanzhou, China
Effect of Remimazolam on Motor Evoked Potential
- First Posted Date
- 2022-07-12
- Last Posted Date
- 2023-03-15
- Lead Sponsor
- Korea University Guro Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT05453955
- Locations
- 🇰🇷
Seok Kyeong Oh, Seoul, Gangnam-gu, Korea, Republic of
Vasopressor Requirements Depends on Sedation Strategy
- First Posted Date
- 2022-07-11
- Last Posted Date
- 2022-07-12
- Lead Sponsor
- Anesthesia Research Group UA
- Target Recruit Count
- 356
- Registration Number
- NCT05451381
- Locations
- 🇺🇦
Cardiosurgery departments with intensive care block, Kyiv, Ukraine
Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-07-11
- Last Posted Date
- 2022-07-11
- Lead Sponsor
- Anesthesia Research Group UA
- Target Recruit Count
- 356
- Registration Number
- NCT05451121
- Locations
- 🇺🇦
Anesthesia department Medical Network Dobrobut, Kyiv, Ukraine
Effect of Sedative Agent on Reducing the Frequency of Arrhythmia in the Patients After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-07-08
- Last Posted Date
- 2022-07-08
- Lead Sponsor
- Anesthesia Research Group UA
- Target Recruit Count
- 356
- Registration Number
- NCT05450497
- Locations
- 🇺🇦
Medical Network Dobrobut, Kyiv, Ukraine
Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial
- First Posted Date
- 2022-07-05
- Last Posted Date
- 2022-07-07
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 60
- Registration Number
- NCT05442905
Drug Development Updates
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