DeepMed Research

Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Pro-Epileptic Effects of IV Ketamine

Phase 4

Active, not recruiting

Conditions: Epilepsy
Seizure

Interventions: Drug: Ketamine
Drug: Midazolam
Drug: Propofol

First Posted Date: 2024-12-19

Last Posted Date: 2024-12-20

Lead Sponsor: Haseki Training and Research Hospital

Target Recruit Count: 300

Registration Number: NCT06741930

Locations: 🇹🇷
Haseki Training and Research Hospital, Istanbul, Turkey

Balanced Analgosedation in Bronchoscopy: Propofol/Pethidine Versus Midazolam/Pethidine

Phase 4

Not yet recruiting

Conditions: Sedation During Bronchoscopy

Interventions: Drug: Propofol 1%
Drug: Midazolam
Drug: Pethidine

First Posted Date: 2024-12-17

Last Posted Date: 2024-12-17

Lead Sponsor: Fondazione Andrea Cesalpino Arezzo ONLUS

Target Recruit Count: 530

Registration Number: NCT06736938

Locations: 🇮🇹
San Donato Hospital, Arezzo, Italy

Comparing the Synergistic Effect of Caudal Dexmedetomidine and Propofol Versus Caudal Dexmedetomidine Only or Propofol Only in Prevention of Sevoflurane Related Emergence Agitation in Pediatric Patients Undergoing Congenital Inguinal Hernia Repair

Phase 4

Not yet recruiting

Conditions: Sevoflurane Agitiion in Pediatric

Interventions: Drug: Propofol alone
Drug: Dexmedetomidine
Drug: dexmedetomidine + propofol

First Posted Date: 2024-12-16

Last Posted Date: 2024-12-16

Lead Sponsor: Assiut University

Target Recruit Count: 90

Registration Number: NCT06734195

Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery

Not Applicable

Recruiting

Conditions: Pediatric Hernia
Laparoscopic Surgery
Appendicitis, Surgery

Interventions: Drug: Ciprofol
Drug: Propofol

First Posted Date: 2024-12-16

Last Posted Date: 2025-05-11

Lead Sponsor: Tongji Hospital

Target Recruit Count: 86

Registration Number: NCT06735430

Locations: 🇨🇳
Tongji hospital, Wuhan, Hubei, China

Clinical Study of Fospropofol Disodium for Injection in the Painless Endoscopic Diagnosis and Treatment

Not Applicable

Not yet recruiting

Conditions: Efficacy and Safety

Interventions: Drug: fospropofol Disodium for injection
Drug: Propofol

First Posted Date: 2024-12-13

Last Posted Date: 2024-12-13

Lead Sponsor: Affiliated Hospital of Nantong University

Target Recruit Count: 426

Registration Number: NCT06732427

Locations: 🇨🇳
Yongtao Gao, Nantong, Jiangsu, China

Propofol vs Sevoflurane in Cardiac Surgery

Not Applicable

Not yet recruiting

Conditions: Cardiac Complications
Cardiac Surgery
Neurologic Complications
Respiratory Complications

Interventions: Drug: sedation using propofol
Drug: sedation using sevoflurane

First Posted Date: 2024-12-11

Last Posted Date: 2024-12-11

Lead Sponsor: Saint-Joseph University

Target Recruit Count: 100

Registration Number: NCT06729086

How Are Cognitive Functions Affected by Different Sedation Methods in Geriatric Patients?

Completed

Conditions: Cognition
Sedation for Gastroenteric Endoscopic Procedure
Geriatric Patients

Interventions: Drug: Propofol group
Drug: Dexmedetomidine group

First Posted Date: 2024-12-06

Last Posted Date: 2024-12-06

Lead Sponsor: Ankara City Hospital Bilkent

Target Recruit Count: 184

Registration Number: NCT06719960

Locations: 🇹🇷
Ankara Bilkent City Hospital, Ankara, Turkey

The Efficacy and Safety of Remimazolam Besylate for Cardiac Anesthesia

Early Phase 1

Not yet recruiting

Conditions: Anesthesia

Interventions: Drug: remimazolam besylate
Drug: propofol

First Posted Date: 2024-12-05

Last Posted Date: 2024-12-05

Lead Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital

Target Recruit Count: 320

Registration Number: NCT06717945

Remimazolam Besylate in Sedation of Postcardioperative Patients

Not Applicable

Recruiting

Conditions: Remimazolam
Propofol
Sedation
Mechanical Ventilation
Intensive Care
Cardiac Surgery

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2024-12-04

Last Posted Date: 2025-02-18

Lead Sponsor: First Affiliated Hospital of Zhejiang University

Target Recruit Count: 120

Registration Number: NCT06716840

Locations: 🇨🇳
First afflilated hospital of zhejiang university school of medicine, Hangzhou, Zhejiang, China

Effect of Propofol Administration Time on the Incidence and Severity of Intrathecal Morphine-induced Pruritus in Parturient Undergoing Elective Cesarean Delivaries

Phase 4

Not yet recruiting

Conditions: Cesarean Section

Interventions: Drug: Morphine intrathecal
Drug: propofol

First Posted Date: 2024-12-04

Last Posted Date: 2024-12-04

Lead Sponsor: Assiut University

Target Recruit Count: 204

Registration Number: NCT06715657

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