Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells

Early Phase 1

Active, not recruiting

Conditions: Anesthesia
Cancer Recurrence
Cancer

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2024-10-04

Last Posted Date: 2025-05-04

Lead Sponsor: Saint Petersburg State University, Russia

Target Recruit Count: 10

Registration Number: NCT06626711

Locations: 🇷🇺
Saint Petersburg State University Hospital, Saint Petersburg, Russian Federation

The Impact of Preoperative Suggestion on Dreaming

Not Applicable

Completed

Conditions: Dream, Day
Ketamine Adverse Reaction
Propofol Adverse Reaction

Interventions: Other: Control Group
Other: Suggestion Group

First Posted Date: 2024-09-24

Last Posted Date: 2025-02-25

Lead Sponsor: Wonkwang University Hospital

Target Recruit Count: 250

Registration Number: NCT06609538

Locations: 🇰🇷
WonwangUH, Iksan, Please Select, Korea, Republic of

Efficacy and Safety of Fospropofol in Adult Laparoscopic Surgery: A Clinical Trial

Phase 4

Recruiting

Conditions: Drug Safety

Interventions: Drug: Propofol
Drug: Fospropofol

First Posted Date: 2024-08-27

Last Posted Date: 2025-04-16

Lead Sponsor: Hui Xu

Target Recruit Count: 373

Registration Number: NCT06573489

Locations: 🇨🇳
Tongji Hospital, Wuhan, Hubei, China

The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

Phase 4

Recruiting

Conditions: Sepsis
Septic Shock
Acute Kidney Injury

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2024-08-26

Last Posted Date: 2024-10-09

Lead Sponsor: Cairo University

Target Recruit Count: 128

Registration Number: NCT06570187

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Effect of Remazolam on Hemodynamics During Hepatectomy

Phase 4

Completed

Conditions: Hemodynamic Instability

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2024-08-22

Last Posted Date: 2025-03-18

Lead Sponsor: Jun Zhang

Target Recruit Count: 70

Registration Number: NCT06565715

Locations: 🇨🇳
Fudan University Shanghai Cancer Center, Shanghai, China
🇨🇳
Fudan University Shanghai Cancer Center, Shanghai, China

Laparoscopic Transversus Abdominis Plane Block Versus Erector Spinae Plane Block in Bariatric Surgery

Not Applicable

Completed

Conditions: Analgesia
Pain, Postoperative
Obesity

Interventions: Procedure: Erector spinae block
Procedure: Transversus abdominis block
Procedure: Bariatric surgery
Device: Endotracheal intubation
Drug: Propofol

First Posted Date: 2024-08-21

Last Posted Date: 2025-01-13

Lead Sponsor: Cairo University

Target Recruit Count: 96

Registration Number: NCT06564610

Locations: 🇪🇬
Faculty of medicine, Cairo University., Cairo, Egypt

Paracetamol Plus Tramadol Versus Fentanyl As Preemptive Analgesia For Enhanced Recovery After Day Case Surgeries

Early Phase 1

Conditions: Preemptive Paracetamol Plus Tramadol and Preemptive Fentanyl

Interventions: Drug: tramadol plus paracetamol
Drug: Fentanyl
Drug: propofol and muscle relaxant (cisatracurium)
Drug: Propofol

First Posted Date: 2024-08-20

Last Posted Date: 2024-08-20

Lead Sponsor: Zagazig University

Target Recruit Count: 102

Registration Number: NCT06561672

Locations: 🇪🇬
Aculty of Medicine,Zagazig University, Zagazig, El Sharkia, Egypt

Sedation in ICU Patients With Mechanical Ventilation

Not Applicable

Not yet recruiting

Conditions: Hypnotics and Sedatives
Respiration, Artificial

Interventions: Drug: Sedation with Ciprofol
Drug: Sedation with Propofol

First Posted Date: 2024-08-06

Last Posted Date: 2024-08-06

Lead Sponsor: Zhongda Hospital

Target Recruit Count: 366

Registration Number: NCT06538883

Study on Gynecological Laparoscopy Under Total Intravenous Anesthesia

Not Applicable

Completed

Conditions: Butorphanol

Interventions: Drug: tartaric acid butorphanol
Drug: normal saline
Drug: propofol and remifentanil

First Posted Date: 2024-07-29

Last Posted Date: 2024-07-29

Lead Sponsor: Wuhan Children's Hospital

Target Recruit Count: 59

Registration Number: NCT06524596

Locations: 🇨🇳
Wuhan Children's hospital, Wuhan, China

Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia

Phase 4

Completed

Conditions: Hip Fracture

Interventions: Drug: Propofol
Drug: Remimazolam
Drug: Flumazenil

First Posted Date: 2024-07-22

Last Posted Date: 2024-07-24

Lead Sponsor: Central South University

Target Recruit Count: 136

Registration Number: NCT06513923

Locations: 🇨🇳
Department of Anesthesiology, The Second Xiangya Hospital, Changsha, Hunan, China
🇨🇳
The Second Xiangya Hospital, Changsha, Hunan, China

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy