Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
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The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects

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2012-03-20
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Exploratory Study of Propofol and Fentanyl Pharmacodynamics

Phase 1
Completed
Conditions
General Anesthesia
Interventions
Drug: propofol
First Posted Date
2012-03-12
Last Posted Date
2012-07-23
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Ethicon Endo-Surgery
Target Recruit Count
20
Registration Number
NCT01550770
Locations
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University of Utah, Salt Lake City, Utah, United States

Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients

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Conditions
Idiopathic Scoliosis
Interventions
Drug: propofol
Drug: Desflurane
First Posted Date
2012-03-09
Last Posted Date
2015-02-26
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Comparison of Dexmedetomidine and Propofol-Remifentanil Conscious Sedation for Awake Craniotomy for Tumor Surgery

Not Applicable
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Conditions
Brain Tumor
Interventions
Drug: Dexmedetomidine
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2012-03-06
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2016-07-07
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Nicolai Goettel
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50
Registration Number
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🇨🇦

UHN Toronto Western Hospital, Toronto, Ontario, Canada

EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

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First Posted Date
2012-03-05
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2022-01-11
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Massachusetts General Hospital
Target Recruit Count
36
Registration Number
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Massachusetts General Hospital, Boston, Massachusetts, United States

Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP)

First Posted Date
2012-02-28
Last Posted Date
2012-02-28
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205
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Gastroenterology Unit, King Chulalongkorn Memorial Hospital, Patumwan, Bangkok, Thailand

Pharmacokinetics of Propofol in Morbidly Obese Patients

Phase 4
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Conditions
Obesity, Morbid
Interventions
Drug: Propofol
First Posted Date
2012-02-20
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Target Recruit Count
69
Registration Number
NCT01536002
Locations
🇳🇴

Oslo University Hospital, Oslo, Norway

Decreasing the Use of Unmodified Electroconvulsive Therapy (ECT) in an Indian Hospital

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Bipolar Disorder
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Sedation MRI - Propofol Versus Propofol-Ketamin in Children

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347
Registration Number
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