Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam

Phase 4

Withdrawn

Conditions: Respiration, Artificial
Alcoholism

Interventions: Drug: Propofol
Drug: Midazolam

First Posted Date: 2009-03-30

Last Posted Date: 2016-03-01

Lead Sponsor: Virginia Commonwealth University

Registration Number: NCT00871039

Locations: 🇺🇸
Virginia Commonwealth University Medical Center (formerly known as Medical College of Virginia), Richmond, Virginia, United States
🇺🇸
Virginia Commonwealth University Medical Center, Richmond, Virginia, United States

Sedation and Pain (The Effect of IV Sedation on Pain Perception)

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: midazolam
Drug: dexmedetomidine
Drug: propofol

First Posted Date: 2009-03-02

Last Posted Date: 2014-06-26

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 86

Registration Number: NCT00853333

Locations: 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States

Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery

Phase 3

Completed

Conditions: Cranitomy Surgery

Interventions: Drug: Propofol
Drug: Precedex

First Posted Date: 2009-02-23

Last Posted Date: 2012-02-10

Lead Sponsor: The Cooper Health System

Target Recruit Count: 15

Registration Number: NCT00848991

Locations: 🇺🇸
Cooper University Hospital, Camden, New Jersey, United States

Bronchoscopy and Bispectral Index (BIS) - Guided Sedation

Phase 4

Completed

Conditions: Bronchoscopy

Interventions: Drug: Midazolam
Drug: Propofol

First Posted Date: 2009-02-09

Last Posted Date: 2009-02-09

Lead Sponsor: University Hospital, Geneva

Target Recruit Count: 84

Registration Number: NCT00839371

Locations: 🇨🇭
Centre Valaisan de Pneumologie, Montana, Switzerland

Safe Administration of Propofol for Sedation in Children

Not Applicable

Completed

Conditions: Sedation

Interventions: Drug: Propofol

First Posted Date: 2009-01-29

Last Posted Date: 2009-08-18

Lead Sponsor: University of British Columbia

Target Recruit Count: 120

Registration Number: NCT00832013

Locations: 🇨🇦
BC Children's Hospital, Department of Anesthesia, Vancouver, British Columbia, Canada

Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation

Phase 4

Completed

Conditions: Subarachnoid Hemorrhage
Stroke

Interventions: Drug: Isoflurane
Drug: Propofol

First Posted Date: 2009-01-28

Last Posted Date: 2016-08-22

Lead Sponsor: Azienda Ospedaliera San Gerardo di Monza

Target Recruit Count: 13

Registration Number: NCT00830843

Locations: 🇮🇹
Azienda Ospedaliera San Gerardo, Monza, Italy

Sevoflurane in Cardiac Surgery

Phase 4

Completed

Conditions: Anesthesia
Cardiac Surgery

Interventions: Drug: propofol
Drug: sevoflurane

First Posted Date: 2009-01-13

Last Posted Date: 2015-10-14

Lead Sponsor: Università Vita-Salute San Raffaele

Target Recruit Count: 200

Registration Number: NCT00821262

Locations: 🇮🇹
Azienda Ospedaliera di Padova, Padova, Italy
🇮🇹
Vita-Salute University, Milano, Italy
🇮🇹
Azienda Ospedaliera di Perugia (H Santa Maria della Misericordia), Perugia, Italy

and more 2 locations