Succinylcholine

Generic Name: Succinylcholine

Brand Names: Anectine, Quelicin

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₃₀N_₂O_₄

CAS Number: 306-40-1

Unique Ingredient Identifier: J2R869A8YF

Background: Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.

Indication: Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions: -

Associated Therapies: Tracheal Intubation

Clinical Trials

Mask Ventilation Before and After Neuromuscular Blockade

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Rocuronium
Drug: Vecuronium Bromide
Drug: Succinylcholine

First Posted Date: 2014-09-11

Last Posted Date: 2015-04-09

Lead Sponsor: University of Washington

Target Recruit Count: 210

Registration Number: NCT02237443

Locations: 🇺🇸
Harborview Medical Center, Seattle, Washington, United States

Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy

Not Applicable

Suspended

Conditions: Patient Satisfaction
Intubating Conditions
Postoperative Myalgia

Interventions: Drug: Rocuronium 0,6
Drug: Rocuronium 0,3
Drug: Succinylcholine

First Posted Date: 2013-11-27

Last Posted Date: 2017-04-04

Lead Sponsor: Dr. Horst Schmidt Klinik GmbH

Target Recruit Count: 150

Registration Number: NCT01996358

Locations: 🇩🇪
Dr. Horst Schmidt Klinik, Wiesbaden, Hessen, Germany

Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy

Not Applicable

Completed

Conditions: Performance With Respiratory Exercise Device
Postoperative Myalgia
Intubating Conditions

Interventions: Drug: Mivacurium
Drug: Succinylcholine

First Posted Date: 2013-10-21

Last Posted Date: 2014-07-30

Lead Sponsor: Dr. Horst Schmidt Klinik GmbH

Target Recruit Count: 100

Registration Number: NCT01966484

Locations: 🇩🇪
Dr. Horst Schmidt Klinik GmbH, Wiesbaden, Germany

Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine

Phase 4

Completed

Conditions: Cesarean Section

Interventions: Drug: Rocuronium
Drug: Succinylcholine

First Posted Date: 2013-09-13

Last Posted Date: 2019-02-11

Lead Sponsor: Charles University, Czech Republic

Target Recruit Count: 91

Registration Number: NCT01941628

Locations: 🇨🇿
General University Hospital in Prague, Prague, Czechia

Enhancing the Effectiveness of Electroconvulsive Therapy in Severe Depression

Phase 4

Completed

Conditions: Depression

Interventions: Device: ECT Mecta 5000M
Drug: Methohexitone
Drug: Suxamethonium

First Posted Date: 2013-07-24

Last Posted Date: 2018-11-14

Lead Sponsor: St Patrick's Hospital, Ireland

Target Recruit Count: 138

Registration Number: NCT01907217

Locations: 🇮🇪
St Patrick's University Hospital, Dublin, Ireland

Muscle Relaxation for Short Procedures

Not Applicable

Completed

Conditions: Intubating Conditions
Fasciculations
Postoperative Myalgia
Patient Satisfaction
Sore Throat

Interventions: Drug: Rocuronium/Sugammadex
Drug: Succinylcholine
Drug: Rocuronium

First Posted Date: 2013-07-18

Last Posted Date: 2013-07-18

Lead Sponsor: Dr. Horst Schmidt Klinik GmbH

Target Recruit Count: 105

Registration Number: NCT01902641

Locations: 🇩🇪
Dr. Horst Schmidt Kliniken, Wiesbaden, Germany

Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia

Phase 4

Terminated

Conditions: Anesthesia

Interventions: Drug: succinylcholine
Drug: rocuronium

First Posted Date: 2012-04-18

Last Posted Date: 2016-11-03

Lead Sponsor: Hopital Foch

Target Recruit Count: 6

Registration Number: NCT01579864

Locations: 🇫🇷
Hopital Foch, Suresnes, Ile de France, France

Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study

Phase 2

Completed

Conditions: Intubation Conditions

Interventions: Drug: Magnesium perfusion
Drug: Placebo perfusion
Drug: Rocuronium
Drug: Succinylcholine

First Posted Date: 2012-04-05

Last Posted Date: 2015-07-20

Lead Sponsor: University Hospital, Geneva

Target Recruit Count: 280

Registration Number: NCT01571908

Locations: 🇨🇭
University Hospital of Geneva, Anesthesia Department, Geneva, Canton of Geneva, Switzerland
🇨🇭
Division of Anaesthesiology, University Hospital of Lausanne (CHUV), Lausanne, Vaud, Switzerland