Succinylcholine

Generic Name: Succinylcholine

Brand Names: Anectine, Quelicin

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₃₀N_₂O_₄

CAS Number: 306-40-1

Unique Ingredient Identifier: J2R869A8YF

Background: Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.

Indication: Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Therapies: Tracheal Intubation

Clinical Trials

Neurorestorative Effects of Electroconvulsive Therapy (ECT) in Patients With Severe Late Life Depression

Not Applicable

Completed

Conditions: Depression

Interventions: Procedure: ECT
Drug: Etomidate
Drug: Succinylcholine

First Posted Date: 2016-01-28

Last Posted Date: 2016-01-28

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 110

Registration Number: NCT02667353

Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery

Phase 4

Completed

Conditions: Neuromuscular Blockade
Postoperative Complications

Interventions: Drug: Cisatracurium
Drug: Succinylcholine

First Posted Date: 2015-12-21

Last Posted Date: 2018-07-17

Lead Sponsor: University of Chicago

Target Recruit Count: 100

Registration Number: NCT02635542

Locations: 🇺🇸
University of Chicago Medicine, Chicago, Illinois, United States

Fade Upon TOF Stimulation Induced by Succinylcholine

Phase 4

Completed

Conditions: Muscle Relaxants

Interventions: Drug: Succinylcholine

First Posted Date: 2015-04-24

Last Posted Date: 2018-01-02

Lead Sponsor: University of Toledo Health Science Campus

Target Recruit Count: 19

Registration Number: NCT02425449

Locations: 🇺🇸
University of Toledo, Health Science Campus, Toledo, Ohio, United States

Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104)

Phase 4

Withdrawn

Conditions: Neuromuscular Blockade

Interventions: Drug: Rocuronium
Drug: Cisatracurium
Drug: Neostigmine/Atropine
Drug: Sugammadex
Drug: Succinylcholine

First Posted Date: 2015-04-07

Last Posted Date: 2015-07-13

Lead Sponsor: Merck Sharp & Dohme LLC

Registration Number: NCT02410590

Mask Ventilation Before and After Neuromuscular Blockade

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Rocuronium
Drug: Vecuronium Bromide
Drug: Succinylcholine

First Posted Date: 2014-09-11

Last Posted Date: 2015-04-09

Lead Sponsor: University of Washington

Target Recruit Count: 210

Registration Number: NCT02237443

Locations: 🇺🇸
Harborview Medical Center, Seattle, Washington, United States

Succinylcholine vs Rocuronium for Prehospital Emergency Intubation

Phase 3

Completed

Conditions: Respiratory Distress
Coma
Major Trauma
Shock

First Posted Date: 2013-12-04

Last Posted Date: 2017-12-15

Lead Sponsor: Centre Hospitalier Universitaire de la Réunion

Target Recruit Count: 1321

Registration Number: NCT02000674

Locations: 🇫🇷
CHU Necker, Paris, France
🇫🇷
CHU de La Réunion, Saint Denis, La Réunion, France
🇫🇷
CHU de la Réunion, Saint Pierre, La Réunion, France

and more 14 locations