Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Decreasing REcurrent Pain and Anxiety in Medical Procedures With a Pediatric Population: Trial
- Conditions
- Interventions
- First Posted Date
- 2016-10-27
- Last Posted Date
- 2018-05-18
- Lead Sponsor
- St. Justine's Hospital
- Registration Number
- NCT02947243
- Locations
- 🇨🇦
CHU Ste. Justine, Montreal, Quebec, Canada
Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy
- First Posted Date
- 2016-10-18
- Last Posted Date
- 2016-10-18
- Lead Sponsor
- Hospital Civil de Guadalajara
- Target Recruit Count
- 64
- Registration Number
- NCT02936934
Paravertebral Morphine Versus Dexmedetomidine on Acute and Chronic Postmastectomy Pain
- Conditions
- Interventions
- First Posted Date
- 2016-10-18
- Last Posted Date
- 2018-01-12
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT02935933
- Locations
- 🇪🇬
Assiut University, Assiut, Iorg0006563, Egypt
Comparison of Efficacy and Safety of the Postoperative Analgesia Methods
- Conditions
- Interventions
- First Posted Date
- 2016-10-11
- Last Posted Date
- 2016-10-11
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 90
- Registration Number
- NCT02929147
- Locations
- 🇹🇷
Ozlem Korkmaz Dilmen, Istanbul, Turkey
Spinal Morphine in Robotic Assisted Radical Prostatectomy
- Conditions
- Interventions
- First Posted Date
- 2016-10-05
- Last Posted Date
- 2018-08-07
- Lead Sponsor
- Maasstad Hospital
- Target Recruit Count
- 160
- Registration Number
- NCT02924974
- Locations
- 🇳🇱
Maasstad Hospital, Rotterdam, Netherlands
Effects of Morphine on Loading-dose Ticagrelor in Patients With ST-segment Elevation Myocardial Infarction
- Conditions
- Interventions
- First Posted Date
- 2016-09-23
- Last Posted Date
- 2020-03-31
- Lead Sponsor
- General Hospital of Chinese Armed Police Forces
- Target Recruit Count
- 128
- Registration Number
- NCT02913469
- Locations
- 🇨🇳
Cardiology Department, Chinese Armed Police Force Genral Hospital, Beijing China, Beijing, China
Dexmedetomidine to Treat Bariatric Surgery-associated Pain
- First Posted Date
- 2016-08-26
- Last Posted Date
- 2021-12-07
- Lead Sponsor
- Janelle Vaughns
- Target Recruit Count
- 26
- Registration Number
- NCT02880540
- Locations
- 🇺🇸
Childrens National Medical Center, Washington, District of Columbia, United States
Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?
- Conditions
- Interventions
- First Posted Date
- 2016-08-26
- Last Posted Date
- 2016-08-26
- Lead Sponsor
- Mount Sinai Hospital, Canada
- Target Recruit Count
- 80
- Registration Number
- NCT02880800
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Analgesic Efficacy of Transmucosal Fentanyl for Breakthrough Pain Caused by Interventional Gastrostomy
- First Posted Date
- 2016-08-16
- Last Posted Date
- 2019-05-13
- Lead Sponsor
- Central Hospital, Nancy, France
- Target Recruit Count
- 20
- Registration Number
- NCT02869321
- Locations
- 🇫🇷
Service ORL - CHU NANCY, Nancy, France
MIdazolam Versus MOrphine in Acute Pulmonary Edema (MIMO Trial)
- First Posted Date
- 2016-08-05
- Last Posted Date
- 2022-06-09
- Lead Sponsor
- Alberto Dominguez-Rodriguez
- Target Recruit Count
- 111
- Registration Number
- NCT02856698
- Locations
- 🇪🇸
Hospital Clínico Universitario San Carlos, Madrid, Spain
🇪🇸Hospital Clínic i Provincial de Barcelona, Barcelona, Cataluña, Spain
🇪🇸Hospital Comarcal de la Axarquía, Málaga, Andalucía, Spain
Drug Development Updates
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