Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Efficacy Study of Rectus Sheath Block to Control Postoperative Pain

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Procedure: ultrasound guided rectus sheath block
Drug: Morphine

First Posted Date: 2014-04-15

Last Posted Date: 2014-04-15

Lead Sponsor: Cukurova University

Target Recruit Count: 40

Registration Number: NCT02115087

Locations: 🇹🇷
Department of Anesthesiology, Cukurova University Faculty of Medicine, Adana, Turkey

A Study of TRV130 for the Treatment of Pain After Bunionectomy

Phase 2

Completed

Conditions: Acute Pain

Interventions: Drug: TRV130
Drug: Placebo
Drug: Morphine

First Posted Date: 2014-04-01

Last Posted Date: 2020-09-16

Lead Sponsor: Trevena Inc.

Target Recruit Count: 333

Registration Number: NCT02100748

Locations: 🇺🇸
Premier Research, Austin, Texas, United States
🇺🇸
Chesapeake Research Group, Pasadena, Maryland, United States
🇺🇸
Jean Brown Research, Salt Lake City, Utah, United States

Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting

Phase 4

Completed

Conditions: Severe Traumatic Pain
Numeric Pain Rating Scale > 5 / 10

Interventions: Drug: Sufentanil
Drug: Morphine
Drug: Placebo

First Posted Date: 2014-03-24

Last Posted Date: 2017-12-13

Lead Sponsor: University Hospital, Grenoble

Target Recruit Count: 194

Registration Number: NCT02095366

Locations: 🇫🇷
Emergency Department - Hospital Annecy, Annecy, France
🇫🇷
Emergency Department - Hospital Albertville, Albertville, France
🇫🇷
Emergency Department - University Hospital of Grenoble, Grenoble, France

and more 3 locations

Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone

Not Applicable

Withdrawn

Conditions: Caesarean Delivery

Interventions: Drug: TAP Block
Drug: Ropivacaine
Drug: Morphine
Drug: Acetaminophen

First Posted Date: 2014-03-19

Last Posted Date: 2016-08-05

Lead Sponsor: Dartmouth-Hitchcock Medical Center

Registration Number: NCT02091297

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
🇺🇸
Brigham & Women's Hospital, Boston, Massachusetts, United States

Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome

Phase 4

Withdrawn

Conditions: Total Knee Arthroplasty

Interventions: Procedure: Adductor canal
Procedure: Femoral
Procedure: Intravenous analgesia
Procedure: Spinal Anesthesia
Procedure: Local anesthetic infusion
Drug: Ropivacaine 0,75%
Drug: Levobupivacaine 0,5%
Drug: Levobupivacaine 0,125%
Drug: Ketorolac 30mg
Drug: Morphine
Device: stimulong sono, Pajunk, Germany

First Posted Date: 2014-03-10

Last Posted Date: 2016-08-09

Lead Sponsor: ASST Gaetano Pini-CTO

Registration Number: NCT02082067

Locations: 🇮🇹
Istituto ortopedico Gaetano Pini, Milan, Italy

Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain

Phase 1

Terminated

Conditions: Cancer

Interventions: Drug: Morphine
Drug: Oxcarbazepine

First Posted Date: 2014-03-05

Last Posted Date: 2017-01-31

Lead Sponsor: Costantine Albany

Target Recruit Count: 1

Registration Number: NCT02078089

Locations: 🇺🇸
Indiana Univeristy Health Hospital, Indianapolis, Indiana, United States
🇺🇸
Indiana University Simon Cancer Center, Indianapolis, Indiana, United States