Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally

Phase 3

Completed

Conditions: Sickle Cell Disease
Pain

Interventions: Drug: Nubain
Drug: Morphine

First Posted Date: 2011-06-27

Last Posted Date: 2018-02-20

Lead Sponsor: Children's Healthcare of Atlanta

Target Recruit Count: 40

Registration Number: NCT01380197

Locations: 🇺🇸
Children's Healthcare of Atlanta, Atlanta, Georgia, United States

Psoas Compartment Block Versus Fascia Iliaca Block After Total Hip Arthroplasty

Not Applicable

Conditions: Pain

Interventions: Drug: Bupivacaine
Drug: Morphine

First Posted Date: 2011-06-23

Last Posted Date: 2011-06-23

Lead Sponsor: Hillel Yaffe Medical Center

Target Recruit Count: 90

Registration Number: NCT01378949

Locations: 🇮🇱
Hillel Yaffe Medical Center, Hadera, Israel

Drug Drug Interactions of Aspirin and P2Y12-inhibitors

Phase 4

Completed

Conditions: Myocardial Infarction
Drug Interaction Potentiation

Interventions: Drug: Placebo
Drug: Morphine

First Posted Date: 2011-06-08

Last Posted Date: 2017-03-27

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 95

Registration Number: NCT01369186

Locations: 🇦🇹
Medical University of Vienna, Department of Clinical Pharmacology, Vienna, Austria

The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Morphine
Drug: Paracetamol- Morphine
Drug: Paracetamol

First Posted Date: 2011-06-06

Last Posted Date: 2012-12-10

Lead Sponsor: Procare Riaya Hospital

Target Recruit Count: 90

Registration Number: NCT01366313

Locations: 🇸🇦
Procare Riaya Hospital, Al Khobar, Estern, Saudi Arabia

Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Morphine Sulfate

First Posted Date: 2011-03-24

Last Posted Date: 2018-02-05

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 50

Registration Number: NCT01322360

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
Stanford University Medical Center, Stanford, California, United States
🇺🇸
University of Texas Health Science Center of Houston, Houston, Texas, United States

and more 8 locations