Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients
- Conditions
- Interventions
- First Posted Date
- 2011-01-20
- Last Posted Date
- 2012-05-17
- Lead Sponsor
- QRxPharma Inc.
- Target Recruit Count
- 375
- Registration Number
- NCT01280331
- Locations
- 🇺🇸
Investigational Site, San Antonio, Texas, United States
🇺🇸Investigational site, Pasadena, Maryland, United States
Morphine Modulation of The Brain's Pain Matrix
- First Posted Date
- 2010-11-22
- Last Posted Date
- 2012-09-21
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 40
- Registration Number
- NCT01245244
- Locations
- 🇩🇰
Department of Gastroenterology, Aalborg Hospital, Aalborg, Denmark
Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study-
- First Posted Date
- 2010-11-04
- Last Posted Date
- 2011-08-16
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 59
- Registration Number
- NCT01234272
- Locations
- 🇰🇷
Severance Hospital, Seoul, Korea, Republic of
Postoperative Pain Control After Hip Hemiarthroplasty: Intrathecal Morphine vs Periarticular Infiltration of Bupivacaine
- Conditions
- Interventions
- First Posted Date
- 2010-10-13
- Last Posted Date
- 2016-10-04
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 10
- Registration Number
- NCT01219062
- Locations
- 🇹🇭
Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
🇹🇭Thitima Chinachot, Bangkok, Thailand
The Optimal Dosage of Intrathecal Morphine for Peripartum Analgesia
- First Posted Date
- 2010-06-17
- Last Posted Date
- 2017-04-25
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 83
- Registration Number
- NCT01146457
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals
- Conditions
- Interventions
- First Posted Date
- 2010-06-03
- Last Posted Date
- 2017-03-03
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 12
- Registration Number
- NCT01136356
- Locations
- 🇺🇸
Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States
A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2010-06-02
- Last Posted Date
- 2010-06-02
- Lead Sponsor
- University of Nottingham
- Target Recruit Count
- 10
- Registration Number
- NCT01134848
- Locations
- 🇬🇧
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
- First Posted Date
- 2010-05-25
- Last Posted Date
- 2010-05-25
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 200
- Registration Number
- NCT01129934
- Locations
- 🇮🇱
Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers
- Conditions
- Interventions
- First Posted Date
- 2010-05-07
- Last Posted Date
- 2011-03-07
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 19
- Registration Number
- NCT01119222
- Locations
- 🇧🇪
Pfizer Investigational Site, Bruxelles, Belgium
Morphine in Acute Abdominal Pain
- First Posted Date
- 2010-04-28
- Last Posted Date
- 2010-04-28
- Lead Sponsor
- Akdeniz University
- Registration Number
- NCT01112540
- Locations
- 🇹🇷
Akdeniz University, Antalya, Turkey
Drug Development Updates
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