Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions

Not Applicable

Completed

Conditions: Pain

First Posted Date: 2009-10-14

Last Posted Date: 2018-01-23

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 18

Registration Number: NCT00994942

Locations: 🇺🇸
CEDRA Clinical Research, Austin, Texas, United States

Comparative Bioavailability Study of Morphine Sulfate Immediate Release and Controlled Release

Not Applicable

Completed

Conditions: Pain

First Posted Date: 2009-10-14

Last Posted Date: 2018-01-23

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 36

Registration Number: NCT00994383

Locations: 🇺🇸
CEDRA Clinical Research, Austin, Texas, United States

Different Approaches to Maternal Hypotension During Cesarean Section

Phase 4

Completed

Conditions: Hypotension
Pregnancy
Cesarean Section
Anesthesia,Spinal

Interventions: Drug: Bupivacaine
Drug: Morphine
Drug: Lactated Ringer's solution
Drug: Ephedrine, continuous infusion
Drug: Ephedrine, bolus
Drug: Atropine

First Posted Date: 2009-10-08

Last Posted Date: 2010-08-27

Lead Sponsor: University of Parma

Target Recruit Count: 36

Registration Number: NCT00991627

Locations: 🇮🇹
University and Hospital of Parma (Azienda Ospedaliero-Universitaria di Parma), Parma, PR, Italy

Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty

Not Applicable

Conditions: Osteoarthritis

Interventions: Drug: ropivacaine, ketorolac and epinephrine
Drug: morphine

First Posted Date: 2009-10-08

Last Posted Date: 2009-10-09

Lead Sponsor: Region Örebro County

Target Recruit Count: 50

Registration Number: NCT00992082

Locations: 🇸🇪
Dept. of Orthopedic Surgery, Orebro, Sweden

Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs

Phase 1

Conditions: Healthy

Interventions: Drug: Nubian with Long dan xie gan tang
Drug: Morphine
Drug: Morphine with Long dan xie gan tang
Drug: Nalbuphine with Long dan xie gan tang
Drug: Nalbuphine

First Posted Date: 2009-06-18

Last Posted Date: 2009-06-19

Lead Sponsor: Tri-Service General Hospital

Target Recruit Count: 50

Registration Number: NCT00923000

Locations: 🇨🇳
Tri-Service General Hospital, Taipei, Taiwan

Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Section

Phase 4

Completed

Conditions: Cesarean Section
Anesthesia,Spinal
Postoperative Nausea and Vomiting

Interventions: Drug: Bupivacaine
Drug: Morphine
Drug: Isotonic saline solution
Drug: Atropine

First Posted Date: 2009-06-16

Last Posted Date: 2009-06-16

Lead Sponsor: University of Parma

Target Recruit Count: 216

Registration Number: NCT00921102

Locations: 🇮🇹
University and Hospital of Parma (Azienda Ospedaliero-Universitaria di Parma), Parma, PR, Italy
🇮🇹
University of Messina, Messina, ME, Italy

Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain

Phase 4

Suspended

Conditions: Chronic Pain

Interventions: Drug: Buprenorphine
Drug: Morphine
Drug: Oxycodone
Drug: Fentanyl

First Posted Date: 2009-06-10

Last Posted Date: 2014-01-09

Lead Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Target Recruit Count: 320

Registration Number: NCT00916890

Locations: 🇮🇹
Servizio di Anestesia e Rianimazione e Terapia Antalgica - Ospedale Sant'Orsola-Poliambulanza, Brescia, Italy
🇮🇹
Servizio di Anestesia e Rianimazione e Terapia Antalgica - Ospedale Mellino Mellini, Chiari, Italy
🇮🇹
Struttura Complessa di Medicina Interna - Ospedale Civile di Voghera - Azienda Ospedaliera provincia di Pavia, Voghera, Pavia, Italy

and more 3 locations