Morphine

Generic Name
Morphine
Brand Names
Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
Drug Type
Small Molecule
Chemical Formula
C17H19NO3
CAS Number
57-27-2
Unique Ingredient Identifier
76I7G6D29C
Background

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorp...

Indication

Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions
Chronic Pain, Severe Pain
Associated Therapies
-
Clinical Trials
Related News

A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery (Study P05800)

Phase 2
Terminated
Conditions
Analgesia
Interventions
Drug: Placebo
Drug: Org 28611
Drug: morphine sulfate
First Posted Date
2008-10-31
Last Posted Date
2015-09-14
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
11
Registration Number
NCT00782951

Intraoperative and Postoperative Analgesia for Laparoscopic Surgery.

First Posted Date
2008-10-15
Last Posted Date
2010-09-22
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
40
Registration Number
NCT00772187
Locations
🇮🇱

Rambam Health Care Campus, Haifa, Israel

Methadone in Pediatric and Adult Sickle Cell Patients

Not Applicable
Completed
Conditions
Sickle Cell Disease
Interventions
Drug: Methadone
Drug: Morphine
First Posted Date
2008-09-26
Last Posted Date
2020-01-22
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
47
Registration Number
NCT00761085
Locations
🇺🇸

Barnes Jewish Hospital/St. Louis Children's Hospital, Saint Louis, Missouri, United States

Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fed Conditions

First Posted Date
2008-09-25
Last Posted Date
2010-08-17
Lead Sponsor
Actavis Inc.
Target Recruit Count
36
Registration Number
NCT00759356
Locations
🇺🇸

CEDRA Clinical Research, LLC, Austin, Texas, United States

Study to Determine the Bioavailability, Pharmacodynamic Effects, and Safety of Whole and Crushed ALO-01 Compared to Morphine Sulfate Immediate Release (MSIR)

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: ALO-01
Drug: MSIR
Drug: Placebo
First Posted Date
2008-09-12
Last Posted Date
2013-09-16
Lead Sponsor
Pfizer
Target Recruit Count
32
Registration Number
NCT00751478
Locations
🇨🇦

DecisionLine Clinical Research, Toronto, Ontario, Canada

Hormone Function in Men Treated for Pain With Opioids or Placebo

Phase 4
Completed
Conditions
Osteoarthritis
Chronic Pain
Interventions
Drug: Placebo
Drug: MS Contin
First Posted Date
2008-08-20
Last Posted Date
2015-04-29
Lead Sponsor
National Institute of Nursing Research (NINR)
Target Recruit Count
8
Registration Number
NCT00737737
Locations
🇺🇸

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery

Phase 3
Completed
Conditions
Scoliosis
Interventions
Other: Saline
Drug: Morphine
First Posted Date
2008-08-20
Last Posted Date
2014-11-19
Lead Sponsor
The Hospital for Sick Children
Target Recruit Count
40
Registration Number
NCT00737997
Locations
🇨🇦

The Hospital for Sick Children, Toronto, Ontario, Canada

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

First Posted Date
2008-08-01
Last Posted Date
2020-09-24
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
1
Registration Number
NCT00726830
Locations
🇺🇸

Palmetto Hematology Oncology, PC at Gibbs Regional Cancer Center, Spartanburg, South Carolina, United States

🇺🇸

M. D. Anderson Cancer Center at University of Texas, Houston, Texas, United States

Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion

Not Applicable
Completed
Conditions
Postoperative Pain
Interventions
Drug: Placebo
Drug: Gabapentin
Drug: Morphine
First Posted Date
2008-08-01
Last Posted Date
2019-04-03
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
63
Registration Number
NCT00726999

Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer

First Posted Date
2008-07-10
Last Posted Date
2021-03-26
Lead Sponsor
Institut Bergonié
Target Recruit Count
78
Registration Number
NCT00712712
Locations
🇫🇷

Institute Bergonié, Bordeaux, France

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