Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Methadone in Pediatric and Adult Sickle Cell Patients

Not Applicable

Completed

Conditions: Sickle Cell Disease

Interventions: Drug: Methadone
Drug: Morphine

First Posted Date: 2008-09-26

Last Posted Date: 2020-01-22

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 47

Registration Number: NCT00761085

Locations: 🇺🇸
Barnes Jewish Hospital/St. Louis Children's Hospital, Saint Louis, Missouri, United States

Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fed Conditions

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: morphine sulfate sustained-release capsules
Drug: KADIAN

First Posted Date: 2008-09-25

Last Posted Date: 2010-08-17

Lead Sponsor: Actavis Inc.

Target Recruit Count: 36

Registration Number: NCT00759356

Locations: 🇺🇸
CEDRA Clinical Research, LLC, Austin, Texas, United States

Study to Determine the Bioavailability, Pharmacodynamic Effects, and Safety of Whole and Crushed ALO-01 Compared to Morphine Sulfate Immediate Release (MSIR)

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: ALO-01
Drug: MSIR
Drug: Placebo

First Posted Date: 2008-09-12

Last Posted Date: 2013-09-16

Lead Sponsor: Pfizer

Target Recruit Count: 32

Registration Number: NCT00751478

Locations: 🇨🇦
DecisionLine Clinical Research, Toronto, Ontario, Canada

Hormone Function in Men Treated for Pain With Opioids or Placebo

Phase 4

Completed

Conditions: Osteoarthritis
Chronic Pain

Interventions: Drug: Placebo
Drug: MS Contin

First Posted Date: 2008-08-20

Last Posted Date: 2015-04-29

Lead Sponsor: National Institute of Nursing Research (NINR)

Target Recruit Count: 8

Registration Number: NCT00737737

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery

Phase 3

Completed

Conditions: Scoliosis

Interventions: Other: Saline
Drug: Morphine

First Posted Date: 2008-08-20

Last Posted Date: 2014-11-19

Lead Sponsor: The Hospital for Sick Children

Target Recruit Count: 40

Registration Number: NCT00737997

Locations: 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Not Applicable

Terminated

Conditions: Chronic Myeloproliferative Disorders
Brain and Central Nervous System Tumors
Leukemia
Myelodysplastic Syndromes
Myelodysplastic/Myeloproliferative Neoplasms
Pain
Precancerous Condition
Unspecified Adult Solid Tumor, Protocol Specific
Lymphoma
Lymphoproliferative Disorder

Interventions: Drug: methadone hydrochloride
Drug: morphine sulfate
Drug: oxycodone hydrochloride

First Posted Date: 2008-08-01

Last Posted Date: 2020-09-24

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 1

Registration Number: NCT00726830

Locations: 🇺🇸
Palmetto Hematology Oncology, PC at Gibbs Regional Cancer Center, Spartanburg, South Carolina, United States
🇺🇸
M. D. Anderson Cancer Center at University of Texas, Houston, Texas, United States

Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Placebo
Drug: Gabapentin
Drug: Morphine

First Posted Date: 2008-08-01

Last Posted Date: 2019-04-03

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 63

Registration Number: NCT00726999

Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer

Phase 2

Completed

Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Metastatic Cancer
Pain

Interventions: Drug: Acetaminophen
Drug: Morphine Sulfate
Other: Questionnaire administration
Procedure: Quality-of-life assessment
Procedure: Radiofrequency ablation

First Posted Date: 2008-07-10

Last Posted Date: 2021-03-26

Lead Sponsor: Institut Bergonié

Target Recruit Count: 78

Registration Number: NCT00712712

Locations: 🇫🇷
Institute Bergonié, Bordeaux, France

Ultrasound Guidance for Interscalene Brachial Plexus Block

Phase 4

Completed

Conditions: Shoulder
Orthopedic Surgery
Nerve Block

Interventions: Procedure: Ultrasound-guided continuous interscalene brachial plexus block
Procedure: Continuous interscalene brachial plexus block using electrical nerve stimulation
Drug: Ropivacaine
Drug: Paracetamol
Drug: Morphine
Drug: Fentanyl
Procedure: General anesthesia