Morphine

Generic Name
Morphine
Brand Names
Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
Drug Type
Small Molecule
Chemical Formula
C17H19NO3
CAS Number
57-27-2
Unique Ingredient Identifier
76I7G6D29C
Background

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorp...

Indication

Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions
Chronic Pain, Severe Pain
Associated Therapies
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A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy

First Posted Date
2008-02-07
Last Posted Date
2011-11-16
Lead Sponsor
Grünenthal GmbH
Target Recruit Count
291
Registration Number
NCT00609466
Locations
🇺🇸

Site 103, San Marcos, Texas, United States

🇺🇸

Site 105, San Antonio, Texas, United States

🇺🇸

Site 104, Pasadena, Maryland, United States

and more 3 locations

Methadone Versus Morphine for Cancer-Related Pain

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2007-12-14
Last Posted Date
2016-02-19
Lead Sponsor
Mayo Clinic
Target Recruit Count
1
Registration Number
NCT00573937
Locations
🇺🇸

Mayo Clinic Arizona, Scottsdale, Arizona, United States

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

First Posted Date
2007-11-22
Last Posted Date
2011-08-08
Lead Sponsor
Asker & Baerum Hospital
Target Recruit Count
102
Registration Number
NCT00562627
Locations
🇳🇴

Asker and Baerum Hospital, Rud, Norway

Role of Methadone As Co-Opioid Analgesic

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2007-11-15
Last Posted Date
2016-04-05
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
5
Registration Number
NCT00558870
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2007-11-14
Last Posted Date
2010-03-30
Lead Sponsor
St. Antonius Hospital
Target Recruit Count
150
Registration Number
NCT00558090
Locations
🇳🇱

St antonius Hospital, Nieuwegein, Netherlands

Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery

First Posted Date
2007-11-04
Last Posted Date
2008-12-31
Lead Sponsor
St Vincent's University Hospital, Ireland
Target Recruit Count
45
Registration Number
NCT00553553
Locations
🇮🇪

St. Vincent's University Hospital, Dublin, County Dublin, Ireland

Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy

First Posted Date
2007-09-10
Last Posted Date
2012-01-26
Lead Sponsor
Preben Kjolhede
Target Recruit Count
180
Registration Number
NCT00527332
Locations
🇸🇪

Värnamo Hospital, Värnamo, Sweden

🇸🇪

Eksjö Hospital, Eksjö, Sweden

🇸🇪

Ryhov Hospital, Jönköping, Sweden

and more 2 locations

Assessment of Opioid Analgesia in Sickle Cell

First Posted Date
2007-08-09
Last Posted Date
2014-12-23
Lead Sponsor
Children's National Research Institute
Registration Number
NCT00513864
Locations
🇺🇸

Children's National Medical Center, Washington, District of Columbia, United States

An Analgesia Protocol for Acute Renal Colic in the Emergency Department

Not Applicable
Completed
Conditions
First Posted Date
2007-07-19
Last Posted Date
2007-10-18
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Target Recruit Count
45
Registration Number
NCT00504283
Locations
🇺🇸

DHMC, Lebanon, New Hampshire, United States

Optimizing the Use of Morphine in Pre-Term Neonates

Phase 2
Completed
Conditions
Interventions
First Posted Date
2007-06-29
Last Posted Date
2016-07-27
Lead Sponsor
John van den Anker
Target Recruit Count
33
Registration Number
NCT00494429
Locations
🇺🇸

Children's National Medical Center, Washington, District of Columbia, United States

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