Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier

Phase 4

Completed

Conditions: Dissecting Aneurysm of the Thoracic Aorta

Interventions: Drug: morphine

First Posted Date: 2009-04-08

Last Posted Date: 2016-06-23

Lead Sponsor: Nova Scotia Health Authority

Target Recruit Count: 35

Registration Number: NCT00878371

Locations: 🇨🇦
Capital Health- Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects

Phase 3

Completed

Conditions: Sedation

Interventions: Drug: Dexmedetomidine
Drug: Midazolam
Drug: Fentanyl
Drug: Morphine

First Posted Date: 2009-04-03

Last Posted Date: 2015-08-14

Lead Sponsor: Hospira, now a wholly owned subsidiary of Pfizer

Target Recruit Count: 175

Registration Number: NCT00875550

Locations: 🇺🇸
Pediatric Critical Care, Los Angeles, California, United States
🇺🇸
Advocate Lutheran General Children's Hospital, Park Ridge, Illinois, United States
🇺🇸
University of Chicago Comer Children's Hospital, Chicago, Illinois, United States

and more 32 locations

Bunionectomy Trial With GRT6005

Phase 2

Completed

Conditions: Post Operative Pain

Interventions: Drug: GRT6005
Drug: Placebo
Drug: Morphine

First Posted Date: 2009-03-31

Last Posted Date: 2021-07-15

Lead Sponsor: Tris Pharma, Inc.

Target Recruit Count: 258

Registration Number: NCT00872885

Locations: 🇺🇸
Premier Research Group Ltd, Austin, Texas, United States

The Effect of Pain Medication in Children With Acute Abdominal Pain and Its Implication Over the Surgeon's Decision

Not Applicable

Withdrawn

Conditions: Abdominal Pain

Interventions: Drug: Morphine Sulfate

First Posted Date: 2009-02-10

Last Posted Date: 2020-06-25

Lead Sponsor: University of Texas Southwestern Medical Center

Registration Number: NCT00839787

Locations: 🇺🇸
Children's Medical Center at Dallas, Dallas, Texas, United States

Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: Q8003
Drug: Oxycodone HCl
Drug: Morphine sulfate
Drug: Oxycodone HCl 4mg

First Posted Date: 2009-01-28

Last Posted Date: 2012-05-17

Lead Sponsor: QRxPharma Inc.

Target Recruit Count: 197

Registration Number: NCT00831051

Locations: 🇺🇸
Chesapeake Foot and Ankle, Pasadena, Maryland, United States
🇺🇸
Associated Foot and Ankle Specialists, Phoenix, Arizona, United States
🇺🇸
Advanced Clinical Research Institute, Anaheim, California, United States

and more 3 locations