Ibuprofen

Generic Name
Ibuprofen
Brand Names
Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph
Drug Type
Small Molecule
Chemical Formula
C13H18O2
CAS Number
15687-27-1
Unique Ingredient Identifier
WK2XYI10QM
Background

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication

Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions
Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain
Associated Therapies
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Hydrocodone For Pain Control in First Trimester Surgical Abortion

First Posted Date
2011-04-07
Last Posted Date
2019-04-26
Lead Sponsor
Elizabeth Micks
Target Recruit Count
121
Registration Number
NCT01330459
Locations
🇺🇸

Planned Parenthood CW, Portland, Oregon, United States

🇺🇸

Oregon Health & Science University, Portland, Oregon, United States

A Study to Test Bioequivalence Between One Test Formulation of Ibuprofen and Two Reference Treatments

Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-03-16
Last Posted Date
2012-07-10
Lead Sponsor
McNeil AB
Target Recruit Count
30
Registration Number
NCT01316978
Locations
🇨🇦

Algorithme Pharma Inc., Mount-Royal, Quebec, Canada

Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain

First Posted Date
2011-03-02
Last Posted Date
2013-08-12
Lead Sponsor
Menarini Group
Target Recruit Count
745
Registration Number
NCT01307020
Locations
🇩🇪

Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Schleswig Holstein, Campus Kiel, Kiel, Schleswig-Holstein, Germany

🇮🇹

Centro di Ricerche Cliniche di Verona Srl. Policlinico G.B.Rossi, Verona, Italy

🇬🇧

University Dental School Manchester, Manchester, England, United Kingdom

and more 13 locations

The Addition of Oral Analgesics to LET During Laceration Repair

Not Applicable
Suspended
Conditions
Interventions
First Posted Date
2010-12-31
Last Posted Date
2013-07-31
Lead Sponsor
Children's Hospitals and Clinics of Minnesota
Target Recruit Count
150
Registration Number
NCT01268670
Locations
🇺🇸

Children's Hospitals and Clinics of Minnesota, Minneapolis and St Paul, Minnesota, United States

High-dose Ibuprofen for Patent Ductus Arteriosus (PDA) in Preterm Infant

Phase 2
Completed
Conditions
Interventions
First Posted Date
2010-11-19
Last Posted Date
2010-11-19
Lead Sponsor
University of Florence
Target Recruit Count
70
Registration Number
NCT01243996
Locations
🇮🇹

Careggi University Hospital, Division of Neonatology, Florence, Italy

The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients

First Posted Date
2010-11-10
Last Posted Date
2021-05-05
Lead Sponsor
University of Rochester
Target Recruit Count
110
Registration Number
NCT01238120
Locations
🇺🇸

University of Rochester, Rochester, New York, United States

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment

First Posted Date
2010-11-07
Last Posted Date
2019-05-10
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
850
Registration Number
NCT01235949
Locations
🇷🇴

GSK Investigational Site, Timisoara, Romania

Pilot Study to Collect and Evaluate Data on the Use of IV* Ibuprofen in the Treatment of an Acute Migraine Attack

Phase 4
Completed
Conditions
Interventions
First Posted Date
2010-10-29
Last Posted Date
2022-09-06
Lead Sponsor
Thomas Jefferson University
Target Recruit Count
44
Registration Number
NCT01230411
Locations
🇺🇸

Jefferson Headache Center, Philadelphia, Pennsylvania, United States

A Study of Aleglitazar in Combination With Ibuprofen in Healthy Volunteers

First Posted Date
2010-08-25
Last Posted Date
2012-05-22
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
44
Registration Number
NCT01188317

Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache

First Posted Date
2010-07-29
Last Posted Date
2010-07-29
Lead Sponsor
Mantecorp Industria Quimica e Farmaceutica Ltd.
Target Recruit Count
144
Registration Number
NCT01172405
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